COVID-19 and its implications for thrombosis
COVID-19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Reported findings indicate that immunosuppression, endothelial activation, and direct viral-mediated tissue damage rather than hyperinflammation-related injury mediates COVID-19 induced organ dysfu...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nizameddin KOCA
2021-04-01
|
| Series: | Turkish Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1481319 |
| _version_ | 1828028222559748096 |
|---|---|
| author | Vildan Ozkocaman |
| author_facet | Vildan Ozkocaman |
| author_sort | Vildan Ozkocaman |
| collection | DOAJ |
| description | COVID-19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Reported findings indicate that immunosuppression, endothelial activation, and direct viral-mediated tissue damage rather than hyperinflammation-related injury mediates COVID-19 induced organ dysfunction. If direct infection drives injury, the vascular tissue is expected to be quite susceptible as it highly expresses angiotensin-converting enzyme-2 (ACE-2), which is essential for coronavirus uptake. Viral injury, disordered cytokine release, and damage-associated molecular patterns (DAMPs) induce localized microvascular inflammation, which triggers endothelial activation, leading to vasodilation and pro-thrombotic conditions. It has been shown that lymphocytes express the ACE-2 receptor on their surfaces thus, SARS-CoV-2 may directly infect those cells and ultimately lead to their lysis. Furthermore, the cytokine storm is characterized by markedly increased levels of interleukins and TNF –alpha, which may promote lymphocyte apoptosis. Apoptosis mediates lymphocyte depletion and inhibitory effects of lactic acid on lymphocyte proliferation. |
| first_indexed | 2024-04-10T13:48:39Z |
| format | Article |
| id | doaj.art-33f5f47838984ae9863142468ef1016f |
| institution | Directory Open Access Journal |
| issn | 2687-4245 |
| language | English |
| last_indexed | 2024-04-10T13:48:39Z |
| publishDate | 2021-04-01 |
| publisher | Nizameddin KOCA |
| record_format | Article |
| series | Turkish Journal of Internal Medicine |
| spelling | doaj.art-33f5f47838984ae9863142468ef1016f2023-02-15T16:10:49ZengNizameddin KOCATurkish Journal of Internal Medicine2687-42452021-04-0132373910.46310/tjim.8513671881COVID-19 and its implications for thrombosisVildan Ozkocaman0Uludağ University, Medical School, Department of HematologyCOVID-19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Reported findings indicate that immunosuppression, endothelial activation, and direct viral-mediated tissue damage rather than hyperinflammation-related injury mediates COVID-19 induced organ dysfunction. If direct infection drives injury, the vascular tissue is expected to be quite susceptible as it highly expresses angiotensin-converting enzyme-2 (ACE-2), which is essential for coronavirus uptake. Viral injury, disordered cytokine release, and damage-associated molecular patterns (DAMPs) induce localized microvascular inflammation, which triggers endothelial activation, leading to vasodilation and pro-thrombotic conditions. It has been shown that lymphocytes express the ACE-2 receptor on their surfaces thus, SARS-CoV-2 may directly infect those cells and ultimately lead to their lysis. Furthermore, the cytokine storm is characterized by markedly increased levels of interleukins and TNF –alpha, which may promote lymphocyte apoptosis. Apoptosis mediates lymphocyte depletion and inhibitory effects of lactic acid on lymphocyte proliferation.https://dergipark.org.tr/tr/download/article-file/1481319covidthrombosisanti-coagulationpathophysiology |
| spellingShingle | Vildan Ozkocaman COVID-19 and its implications for thrombosis Turkish Journal of Internal Medicine covid thrombosis anti-coagulation pathophysiology |
| title | COVID-19 and its implications for thrombosis |
| title_full | COVID-19 and its implications for thrombosis |
| title_fullStr | COVID-19 and its implications for thrombosis |
| title_full_unstemmed | COVID-19 and its implications for thrombosis |
| title_short | COVID-19 and its implications for thrombosis |
| title_sort | covid 19 and its implications for thrombosis |
| topic | covid thrombosis anti-coagulation pathophysiology |
| url | https://dergipark.org.tr/tr/download/article-file/1481319 |
| work_keys_str_mv | AT vildanozkocaman covid19anditsimplicationsforthrombosis |