The Anatomo-Electrical Network Underlying Hypermotor Seizures
PurposeHypermotor seizures (HMS) can be triggered by different epileptogenic foci and thus common symptomatic networks generating HMS may exist among these patients. The goal of the present study was to investigate the specialized networks underlying HMS by analyzing interictal 18FDG-PET imaging and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2018.00243/full |
| _version_ | 1818338883550576640 |
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| author | Xiu Wang Wenhan Hu Wenhan Hu Kai Zhang Kai Zhang Xiaoqiu Shao Yanshan Ma Lin Sang Zhong Zheng Chao Zhang Chao Zhang Junjv Li Jian-guo Zhang Jian-guo Zhang Jian-guo Zhang |
| author_facet | Xiu Wang Wenhan Hu Wenhan Hu Kai Zhang Kai Zhang Xiaoqiu Shao Yanshan Ma Lin Sang Zhong Zheng Chao Zhang Chao Zhang Junjv Li Jian-guo Zhang Jian-guo Zhang Jian-guo Zhang |
| author_sort | Xiu Wang |
| collection | DOAJ |
| description | PurposeHypermotor seizures (HMS) can be triggered by different epileptogenic foci and thus common symptomatic networks generating HMS may exist among these patients. The goal of the present study was to investigate the specialized networks underlying HMS by analyzing interictal 18FDG-PET imaging and ictal stereo-electroencephalography (SEEG) recordings.MethodsFourteen patients with HMS were retrospectively analyzed. HMS were classified into HMS1 and HMS2 according to the speed and intensity of the motor seizure behavior. Then, the interictal PET data of patients was compared with those of 18 healthy controls using statistical parametric mapping to identify regions with significant hypometabolism. Ictal SEEG recordings were reviewed to identify the spreading areas at the beginning of HMS occurrence.ResultsCompared to controls, patients with HMS presented significant hypometabolism in the bilateral anterosuperior insular lobes, mesial premotor cortex (MPMC), middle cingulate cortex (MCC), as well as in the bilateral caudate nuclei. When comparing patients in the two HMS subgroups with controls, more extensive hypometabolic areas were seen in HMS1 patients than in HMS2 patients, including the orbitofrontal cortex (OFC), the temporal pole, and the anterior cingulate cortex (ACC). OFC and ventromedial prefrontal cortex was also found significantly hypometabolic in patients with HMS1 when compared with HMS2 directly. SEEG recordings further suggested that insula, MCC, and MPMC were commonly recruited at the beginning of HMS.ConclusionWe have identified a specialized interictal hypometabolic pattern in patients with HMS. A network involving the anterosuperior insula, mesiofrontal cortex (MCC-MPMC), and caudate nucleus may contribute to the generation of HMS. ACC, OFC, and temporal pole are possibly associated with the affective components of HMS. Our findings provide further insight into understanding the network basis of HMS semiology. |
| first_indexed | 2024-12-13T15:18:11Z |
| format | Article |
| id | doaj.art-33f7421f977644ab9f22cea2d87cafe5 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-13T15:18:11Z |
| publishDate | 2018-04-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-33f7421f977644ab9f22cea2d87cafe52022-12-21T23:40:39ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-04-01910.3389/fneur.2018.00243336285The Anatomo-Electrical Network Underlying Hypermotor SeizuresXiu Wang0Wenhan Hu1Wenhan Hu2Kai Zhang3Kai Zhang4Xiaoqiu Shao5Yanshan Ma6Lin Sang7Zhong Zheng8Chao Zhang9Chao Zhang10Junjv Li11Jian-guo Zhang12Jian-guo Zhang13Jian-guo Zhang14Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaStereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaEpilepsy Center, Medical Alliance of Beijing Tian Tan Hospital, Peking University First Hospital Fengtai Hospital, Beijing, ChinaEpilepsy Center, Medical Alliance of Beijing Tian Tan Hospital, Peking University First Hospital Fengtai Hospital, Beijing, ChinaEpilepsy Center, Medical Alliance of Beijing Tian Tan Hospital, Peking University First Hospital Fengtai Hospital, Beijing, ChinaDepartment of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Neurosurgery, Hainan General Hospital, Haikou, ChinaDepartment of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, ChinaStereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaPurposeHypermotor seizures (HMS) can be triggered by different epileptogenic foci and thus common symptomatic networks generating HMS may exist among these patients. The goal of the present study was to investigate the specialized networks underlying HMS by analyzing interictal 18FDG-PET imaging and ictal stereo-electroencephalography (SEEG) recordings.MethodsFourteen patients with HMS were retrospectively analyzed. HMS were classified into HMS1 and HMS2 according to the speed and intensity of the motor seizure behavior. Then, the interictal PET data of patients was compared with those of 18 healthy controls using statistical parametric mapping to identify regions with significant hypometabolism. Ictal SEEG recordings were reviewed to identify the spreading areas at the beginning of HMS occurrence.ResultsCompared to controls, patients with HMS presented significant hypometabolism in the bilateral anterosuperior insular lobes, mesial premotor cortex (MPMC), middle cingulate cortex (MCC), as well as in the bilateral caudate nuclei. When comparing patients in the two HMS subgroups with controls, more extensive hypometabolic areas were seen in HMS1 patients than in HMS2 patients, including the orbitofrontal cortex (OFC), the temporal pole, and the anterior cingulate cortex (ACC). OFC and ventromedial prefrontal cortex was also found significantly hypometabolic in patients with HMS1 when compared with HMS2 directly. SEEG recordings further suggested that insula, MCC, and MPMC were commonly recruited at the beginning of HMS.ConclusionWe have identified a specialized interictal hypometabolic pattern in patients with HMS. A network involving the anterosuperior insula, mesiofrontal cortex (MCC-MPMC), and caudate nucleus may contribute to the generation of HMS. ACC, OFC, and temporal pole are possibly associated with the affective components of HMS. Our findings provide further insight into understanding the network basis of HMS semiology.http://journal.frontiersin.org/article/10.3389/fneur.2018.00243/fullsemiologyhypermotorinterictal 18FDG-PETstereo-electroencephalographynetworkcingulate cortex |
| spellingShingle | Xiu Wang Wenhan Hu Wenhan Hu Kai Zhang Kai Zhang Xiaoqiu Shao Yanshan Ma Lin Sang Zhong Zheng Chao Zhang Chao Zhang Junjv Li Jian-guo Zhang Jian-guo Zhang Jian-guo Zhang The Anatomo-Electrical Network Underlying Hypermotor Seizures Frontiers in Neurology semiology hypermotor interictal 18FDG-PET stereo-electroencephalography network cingulate cortex |
| title | The Anatomo-Electrical Network Underlying Hypermotor Seizures |
| title_full | The Anatomo-Electrical Network Underlying Hypermotor Seizures |
| title_fullStr | The Anatomo-Electrical Network Underlying Hypermotor Seizures |
| title_full_unstemmed | The Anatomo-Electrical Network Underlying Hypermotor Seizures |
| title_short | The Anatomo-Electrical Network Underlying Hypermotor Seizures |
| title_sort | anatomo electrical network underlying hypermotor seizures |
| topic | semiology hypermotor interictal 18FDG-PET stereo-electroencephalography network cingulate cortex |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2018.00243/full |
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