MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis
The jasmonic acid (JA) signaling pathway plays important roles in plant defenses, development, and the synthesis of specialized metabolites synthesis. Transcription factor MYC2 is a major regulator of the JA signaling pathway and is involved in the regulation of plant physiological processes and spe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3511 |
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| author | Lei Luo Ying Wang Lu Qiu Xingpei Han Yaqian Zhu Lulu Liu Mingwu Man Fuguang Li Maozhi Ren Yadi Xing |
| author_facet | Lei Luo Ying Wang Lu Qiu Xingpei Han Yaqian Zhu Lulu Liu Mingwu Man Fuguang Li Maozhi Ren Yadi Xing |
| author_sort | Lei Luo |
| collection | DOAJ |
| description | The jasmonic acid (JA) signaling pathway plays important roles in plant defenses, development, and the synthesis of specialized metabolites synthesis. Transcription factor MYC2 is a major regulator of the JA signaling pathway and is involved in the regulation of plant physiological processes and specialized metabolite synthesis. Based on our understanding of the mechanism underlying the regulation of specialized metabolite synthesis in plants by the transcription factor MYC2, the use of synthetic biology approaches to design MYC2-driven chassis cells for the synthesis of specialized metabolites with high medicinal value, such as paclitaxel, vincristine, and artemisinin, seems to be a promising strategy. In this review, the regulatory role of MYC2 in JA signal transduction of plants to biotic and abiotic stresses, plant growth, development and specialized metabolite synthesis is described in detail, which will provide valuable reference for the use of MYC2 molecular switches to regulate plant specialized metabolite biosynthesis. |
| first_indexed | 2024-03-11T08:42:44Z |
| format | Article |
| id | doaj.art-33f7f9c212cf42e6bdc1997c4059a086 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:42:44Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-33f7f9c212cf42e6bdc1997c4059a0862023-11-16T21:01:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244351110.3390/ijms24043511MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite SynthesisLei Luo0Ying Wang1Lu Qiu2Xingpei Han3Yaqian Zhu4Lulu Liu5Mingwu Man6Fuguang Li7Maozhi Ren8Yadi Xing9Zhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaInstitute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu 610000, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaState Key Laboratory of Cotton Biology, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang 455000, ChinaZhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaZhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaZhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaZhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaZhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaZhengzhou Research Base, State Key Laboratory of Cotton Biology, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaThe jasmonic acid (JA) signaling pathway plays important roles in plant defenses, development, and the synthesis of specialized metabolites synthesis. Transcription factor MYC2 is a major regulator of the JA signaling pathway and is involved in the regulation of plant physiological processes and specialized metabolite synthesis. Based on our understanding of the mechanism underlying the regulation of specialized metabolite synthesis in plants by the transcription factor MYC2, the use of synthetic biology approaches to design MYC2-driven chassis cells for the synthesis of specialized metabolites with high medicinal value, such as paclitaxel, vincristine, and artemisinin, seems to be a promising strategy. In this review, the regulatory role of MYC2 in JA signal transduction of plants to biotic and abiotic stresses, plant growth, development and specialized metabolite synthesis is described in detail, which will provide valuable reference for the use of MYC2 molecular switches to regulate plant specialized metabolite biosynthesis.https://www.mdpi.com/1422-0067/24/4/3511MYC2jasmonic acid signalingplant physiologyspecialized metabolitesbiosynthesissynthetic biology |
| spellingShingle | Lei Luo Ying Wang Lu Qiu Xingpei Han Yaqian Zhu Lulu Liu Mingwu Man Fuguang Li Maozhi Ren Yadi Xing MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis International Journal of Molecular Sciences MYC2 jasmonic acid signaling plant physiology specialized metabolites biosynthesis synthetic biology |
| title | MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis |
| title_full | MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis |
| title_fullStr | MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis |
| title_full_unstemmed | MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis |
| title_short | MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis |
| title_sort | myc2 a master switch for plant physiological processes and specialized metabolite synthesis |
| topic | MYC2 jasmonic acid signaling plant physiology specialized metabolites biosynthesis synthetic biology |
| url | https://www.mdpi.com/1422-0067/24/4/3511 |
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