Olanzapine-induced tardive oculogyric crises
Tardive syndromes are much lower in prevalence in second generation antipsychotics (SGA) than in the typical antipsychotics. Although, olanzapine, which is an SGA, has a high risk of causing weight gain, metabolic syndrome, raised blood sugar, and dyslipidemias; it is widely used as the risk of deve...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-01-01
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| Series: | Indian Journal of Psychological Medicine |
| Subjects: | |
| Online Access: | http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=4;spage=423;epage=424;aulast=Bavle |
| _version_ | 1818621478341443584 |
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| author | Amar D Bavle Girish M. N. Kumar |
| author_facet | Amar D Bavle Girish M. N. Kumar |
| author_sort | Amar D Bavle |
| collection | DOAJ |
| description | Tardive syndromes are much lower in prevalence in second generation antipsychotics (SGA) than in the typical antipsychotics. Although, olanzapine, which is an SGA, has a high risk of causing weight gain, metabolic syndrome, raised blood sugar, and dyslipidemias; it is widely used as the risk of developing extrapyramidal syndromes (EPS) is low. Among the various forms of EPS, tardive syndromes are the most feared, tardive dyskinesia, tardive akathisia, and tardive dystonia are the commonest tardive syndromes, the others being less common. Tardive oculogyric crises (TOC) are a rare form of tardive dystonia. This patient had TOC with prolonged unsupervised treatment with low-dose olanzapine. Added to that, she developed weight gain that was alarmingly high and such high gain in weight with olanzapine, to our knowledge, has not been reported. She responded to a low dose of trihexiphenydyl, and on stopping olanzapine and adding aripiprazole, has started losing weight. |
| first_indexed | 2024-12-16T18:09:55Z |
| format | Article |
| id | doaj.art-33f81ab26b04422195b1c2c3f2f30e95 |
| institution | Directory Open Access Journal |
| issn | 0253-7176 |
| language | English |
| last_indexed | 2024-12-16T18:09:55Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Psychological Medicine |
| spelling | doaj.art-33f81ab26b04422195b1c2c3f2f30e952022-12-21T22:21:48ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762013-01-0135442342410.4103/0253-7176.122249Olanzapine-induced tardive oculogyric crisesAmar D BavleGirish M. N. KumarTardive syndromes are much lower in prevalence in second generation antipsychotics (SGA) than in the typical antipsychotics. Although, olanzapine, which is an SGA, has a high risk of causing weight gain, metabolic syndrome, raised blood sugar, and dyslipidemias; it is widely used as the risk of developing extrapyramidal syndromes (EPS) is low. Among the various forms of EPS, tardive syndromes are the most feared, tardive dyskinesia, tardive akathisia, and tardive dystonia are the commonest tardive syndromes, the others being less common. Tardive oculogyric crises (TOC) are a rare form of tardive dystonia. This patient had TOC with prolonged unsupervised treatment with low-dose olanzapine. Added to that, she developed weight gain that was alarmingly high and such high gain in weight with olanzapine, to our knowledge, has not been reported. She responded to a low dose of trihexiphenydyl, and on stopping olanzapine and adding aripiprazole, has started losing weight.http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=4;spage=423;epage=424;aulast=BavleAripiprazoleolanzapinetardive oculogyric crisestrihexiphenidylweight gain |
| spellingShingle | Amar D Bavle Girish M. N. Kumar Olanzapine-induced tardive oculogyric crises Indian Journal of Psychological Medicine Aripiprazole olanzapine tardive oculogyric crises trihexiphenidyl weight gain |
| title | Olanzapine-induced tardive oculogyric crises |
| title_full | Olanzapine-induced tardive oculogyric crises |
| title_fullStr | Olanzapine-induced tardive oculogyric crises |
| title_full_unstemmed | Olanzapine-induced tardive oculogyric crises |
| title_short | Olanzapine-induced tardive oculogyric crises |
| title_sort | olanzapine induced tardive oculogyric crises |
| topic | Aripiprazole olanzapine tardive oculogyric crises trihexiphenidyl weight gain |
| url | http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=4;spage=423;epage=424;aulast=Bavle |
| work_keys_str_mv | AT amardbavle olanzapineinducedtardiveoculogyriccrises AT girishmnkumar olanzapineinducedtardiveoculogyriccrises |