Impact of Endoscopic Ultrasound-Guided Tissue Acquisition on Decision-Making in Precision Medicine for Pancreatic Cancer: Beyond Diagnosis
Precision medicine in cancer treatment refers to targeted therapy based on the evaluation of biomarkers. Although precision medicine for pancreatic cancer (PC) remains challenging, novel biomarker-based therapies, such as pembrolizumab, olaparib, and entrectinib, have been emerging. Most commonly, e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/7/1195 |
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| author | Hiroshi Imaoka Mitsuhito Sasaki Yusuke Hashimoto Kazuo Watanabe Shoichi Miyazawa Taro Shibuki Shuichi Mitsunaga Masafumi Ikeda |
| author_facet | Hiroshi Imaoka Mitsuhito Sasaki Yusuke Hashimoto Kazuo Watanabe Shoichi Miyazawa Taro Shibuki Shuichi Mitsunaga Masafumi Ikeda |
| author_sort | Hiroshi Imaoka |
| collection | DOAJ |
| description | Precision medicine in cancer treatment refers to targeted therapy based on the evaluation of biomarkers. Although precision medicine for pancreatic cancer (PC) remains challenging, novel biomarker-based therapies, such as pembrolizumab, olaparib, and entrectinib, have been emerging. Most commonly, endoscopic ultrasound-guided tissue acquisition (EUS-TA) had been used for the diagnosis of PC until now. However, advances in EUS-TA devices and biomarker testing, especially next-generation sequencing, have opened up the possibility of sequencing of various genes even in limited amounts of tissue samples obtained by EUS-TA, and identifying potential genetic alterations as therapeutic targets. Precision medicine benefits only a small population of patients with PC, but biomarker-based therapy has shown promising results in patients who once had no treatment options. Now, the role of EUS-TA has extended beyond diagnosis into decision-making regarding the treatment of PC. In this review, we mainly discuss tissue sampling by EUS-TA for biomarker testing and the current status of precision medicine for PC. |
| first_indexed | 2024-03-10T09:53:34Z |
| format | Article |
| id | doaj.art-33fb512b9a844ca283d57b52262a6b8d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T09:53:34Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-33fb512b9a844ca283d57b52262a6b8d2023-11-22T02:29:45ZengMDPI AGDiagnostics2075-44182021-06-01117119510.3390/diagnostics11071195Impact of Endoscopic Ultrasound-Guided Tissue Acquisition on Decision-Making in Precision Medicine for Pancreatic Cancer: Beyond DiagnosisHiroshi Imaoka0Mitsuhito Sasaki1Yusuke Hashimoto2Kazuo Watanabe3Shoichi Miyazawa4Taro Shibuki5Shuichi Mitsunaga6Masafumi Ikeda7Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, JapanDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, JapanDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, JapanDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, JapanDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, JapanDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, JapanDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, JapanDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, JapanPrecision medicine in cancer treatment refers to targeted therapy based on the evaluation of biomarkers. Although precision medicine for pancreatic cancer (PC) remains challenging, novel biomarker-based therapies, such as pembrolizumab, olaparib, and entrectinib, have been emerging. Most commonly, endoscopic ultrasound-guided tissue acquisition (EUS-TA) had been used for the diagnosis of PC until now. However, advances in EUS-TA devices and biomarker testing, especially next-generation sequencing, have opened up the possibility of sequencing of various genes even in limited amounts of tissue samples obtained by EUS-TA, and identifying potential genetic alterations as therapeutic targets. Precision medicine benefits only a small population of patients with PC, but biomarker-based therapy has shown promising results in patients who once had no treatment options. Now, the role of EUS-TA has extended beyond diagnosis into decision-making regarding the treatment of PC. In this review, we mainly discuss tissue sampling by EUS-TA for biomarker testing and the current status of precision medicine for PC.https://www.mdpi.com/2075-4418/11/7/1195endoscopic ultrasound-guided tissue acquisitionendoscopic ultrasound-guided fine needle aspirationendoscopic ultrasound-guided fine needle biopsynext-generation sequencingprecision medicinepancreatic cancer |
| spellingShingle | Hiroshi Imaoka Mitsuhito Sasaki Yusuke Hashimoto Kazuo Watanabe Shoichi Miyazawa Taro Shibuki Shuichi Mitsunaga Masafumi Ikeda Impact of Endoscopic Ultrasound-Guided Tissue Acquisition on Decision-Making in Precision Medicine for Pancreatic Cancer: Beyond Diagnosis Diagnostics endoscopic ultrasound-guided tissue acquisition endoscopic ultrasound-guided fine needle aspiration endoscopic ultrasound-guided fine needle biopsy next-generation sequencing precision medicine pancreatic cancer |
| title | Impact of Endoscopic Ultrasound-Guided Tissue Acquisition on Decision-Making in Precision Medicine for Pancreatic Cancer: Beyond Diagnosis |
| title_full | Impact of Endoscopic Ultrasound-Guided Tissue Acquisition on Decision-Making in Precision Medicine for Pancreatic Cancer: Beyond Diagnosis |
| title_fullStr | Impact of Endoscopic Ultrasound-Guided Tissue Acquisition on Decision-Making in Precision Medicine for Pancreatic Cancer: Beyond Diagnosis |
| title_full_unstemmed | Impact of Endoscopic Ultrasound-Guided Tissue Acquisition on Decision-Making in Precision Medicine for Pancreatic Cancer: Beyond Diagnosis |
| title_short | Impact of Endoscopic Ultrasound-Guided Tissue Acquisition on Decision-Making in Precision Medicine for Pancreatic Cancer: Beyond Diagnosis |
| title_sort | impact of endoscopic ultrasound guided tissue acquisition on decision making in precision medicine for pancreatic cancer beyond diagnosis |
| topic | endoscopic ultrasound-guided tissue acquisition endoscopic ultrasound-guided fine needle aspiration endoscopic ultrasound-guided fine needle biopsy next-generation sequencing precision medicine pancreatic cancer |
| url | https://www.mdpi.com/2075-4418/11/7/1195 |
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