Acacetin improves cognitive function of APP/PS1 Alzheimer’s disease model mice via the NLRP3 inflammasome signaling pathway

Acacetin improves cognitive function of APP/PS1 Alzheimer’s disease model mice via the NLRP3 inflammasome signaling pathway

Acacetin (5,7-dihydroxy-4′-methoxyflavone), one of the main extractions from Saussurea involucrata, has anti-inflammatory effects. Our previous study found that acacetin inhibited the Nod-like receptor pyrin domain containing 3 (NLRP3) signaling pathway after cerebral ischemia–reperfusion injury. NL...

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Bibliographic Details
Main Authors: Bu Juan, Zhang Yanmin, Mahan Yeledan, Shi Shen, Wu Xuanxia, Zhang Xiaoling, Wang Zhaoxia, Zhou Ling
Format: Article
Language:English
Published: De Gruyter 2022-10-01
Series:Translational Neuroscience
Subjects:
acacetin
alzheimer’s disease
nlrp3 inflammasome
spatial learning and memory
app/ps1 mice
Online Access:https://doi.org/10.1515/tnsci-2022-0254

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