In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats
Diabetes mellitus type two (T2DM) is one of the most extensive diseases in the world. Herbal therapy remains a possible adjunct therapy to sustain better glycemic control and reduce complications arising from diabetes. In order to evaluate the curative impacts of olive leaf extract (OLE) on streptoz...
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| Format: | Article |
| Language: | English |
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Consejo Superior de Investigaciones Científicas
2018-03-01
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| Series: | Grasas y Aceites |
| Subjects: | |
| Online Access: | http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1710 |
| _version_ | 1818612786227314688 |
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| author | A. M.R. Afify H. S. El-Beltagi S. A. Fayed A. E. El-Ansary |
| author_facet | A. M.R. Afify H. S. El-Beltagi S. A. Fayed A. E. El-Ansary |
| author_sort | A. M.R. Afify |
| collection | DOAJ |
| description | Diabetes mellitus type two (T2DM) is one of the most extensive diseases in the world. Herbal therapy remains a possible adjunct therapy to sustain better glycemic control and reduce complications arising from diabetes. In order to evaluate the curative impacts of olive leaf extract (OLE) on streptozotocin (STZ)-induced diabetic rats, twenty-four Wistar male adult rats were divided into four equal groups; control, diabetic control (45 mg/kg STZ), normal rats treated with OLE (17.8 mg/kg b.wt.), and diabetic rats treated with OLE (45 mg/kg STZ + 17.8 mg/kg b.wt.). The OLE extract was investigated for in vitro antioxidant activity using the DPPH• assay. The phenolic, tannin, and flavonoid contents were determined. The activity of GPX, SOD, and GSH in RBC lysate, CAT in plasma and MDA in serum were measured. The OLE prevented the decrease in GSH and kept MDA around the normal range in the treated diabetic rats. The current study suggests that OLE might be used safely to ameliorate T2DM and its accompanying oxidative stress. |
| first_indexed | 2024-12-16T15:51:45Z |
| format | Article |
| id | doaj.art-33fc67e636e9466a952b04a3416933f5 |
| institution | Directory Open Access Journal |
| issn | 0017-3495 1988-4214 |
| language | English |
| last_indexed | 2024-12-16T15:51:45Z |
| publishDate | 2018-03-01 |
| publisher | Consejo Superior de Investigaciones Científicas |
| record_format | Article |
| series | Grasas y Aceites |
| spelling | doaj.art-33fc67e636e9466a952b04a3416933f52022-12-21T22:25:41ZengConsejo Superior de Investigaciones CientíficasGrasas y Aceites0017-34951988-42142018-03-01691e243e24310.3989/gya.11041721677In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in ratsA. M.R. Afify0https://orcid.org/0000-0001-8096-7649H. S. El-Beltagi1https://orcid.org/0000-0003-4433-2034S. A. Fayed2https://orcid.org/0000-0002-3449-6679A. E. El-Ansary3https://orcid.org/0000-0003-0585-1229Biochemistry Dept, Faculty of Agriculture, Cairo UniversityBiochemistry Dept, Faculty of Agriculture, Cairo UniversityBiochemistry Dept, Faculty of Agriculture, Cairo UniversityBiochemistry Dept, Faculty of Agriculture, Cairo UniversityDiabetes mellitus type two (T2DM) is one of the most extensive diseases in the world. Herbal therapy remains a possible adjunct therapy to sustain better glycemic control and reduce complications arising from diabetes. In order to evaluate the curative impacts of olive leaf extract (OLE) on streptozotocin (STZ)-induced diabetic rats, twenty-four Wistar male adult rats were divided into four equal groups; control, diabetic control (45 mg/kg STZ), normal rats treated with OLE (17.8 mg/kg b.wt.), and diabetic rats treated with OLE (45 mg/kg STZ + 17.8 mg/kg b.wt.). The OLE extract was investigated for in vitro antioxidant activity using the DPPH• assay. The phenolic, tannin, and flavonoid contents were determined. The activity of GPX, SOD, and GSH in RBC lysate, CAT in plasma and MDA in serum were measured. The OLE prevented the decrease in GSH and kept MDA around the normal range in the treated diabetic rats. The current study suggests that OLE might be used safely to ameliorate T2DM and its accompanying oxidative stress.http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1710antioxidant enzymes activitydiabetes mellitus type twoflavonoidsolive leaves extractoxidative stressphenolics |
| spellingShingle | A. M.R. Afify H. S. El-Beltagi S. A. Fayed A. E. El-Ansary In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats Grasas y Aceites antioxidant enzymes activity diabetes mellitus type two flavonoids olive leaves extract oxidative stress phenolics |
| title | In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats |
| title_full | In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats |
| title_fullStr | In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats |
| title_full_unstemmed | In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats |
| title_short | In vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin-induced diabetes mellitus in rats |
| title_sort | in vivo correlation of olive leaves extract on some oxidative stress markers in streptozotocin induced diabetes mellitus in rats |
| topic | antioxidant enzymes activity diabetes mellitus type two flavonoids olive leaves extract oxidative stress phenolics |
| url | http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1710 |
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