Preoperative inflammatory markers for predicting parathyroid carcinoma
Objective: Parathyroid carcinoma is a rare tumor among parathyroid tumors. Aspiration cytology and needle biopsy are generally not recommended for diagnostic purposes because they cause dissemination. Therefore, it is commonly diagnosed by postoperative histopathological examination. In this study,...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2022-07-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/11/7/EC-22-0062.xml |
| _version_ | 1818006807081123840 |
|---|---|
| author | Keiko Ohkuwa Kiminori Sugino Ryohei Katoh Mitsuji Nagahama Wataru Kitagawa Kenichi Matsuzu Akifumi Suzuki Chisato Tomoda Kiyomi Hames Junko Akaishi Chie Masaki Kana Yoshioka Koichi Ito |
| author_facet | Keiko Ohkuwa Kiminori Sugino Ryohei Katoh Mitsuji Nagahama Wataru Kitagawa Kenichi Matsuzu Akifumi Suzuki Chisato Tomoda Kiyomi Hames Junko Akaishi Chie Masaki Kana Yoshioka Koichi Ito |
| author_sort | Keiko Ohkuwa |
| collection | DOAJ |
| description | Objective: Parathyroid carcinoma is a rare tumor among parathyroid tumors. Aspiration cytology and needle biopsy are generally not recommended for diagnostic purposes because they cause dissemination. Therefore, it is commonly diagnosed by postoperative histopathological examination. In this study, we investigated whether preoperative inflammatory markers can be used as predictors of cancer in patients with primary hyperparathyroidism.
Design: This was a retrospective study.
Methods: Thirty-six cases of parathyroid carcinoma and 50 cases of parathyroid adenoma (PA) operated with the diagnosis of primary hyperparathyroidism and confirmed histopathologically at Ito Hospital were included in this study. Preoperative clinical characteristics and inflammatory markers (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio (LMR)) were compared and their values in preoperative prediction were evaluated and analyzed.
Results: Preoperative intact-parathyroid hormone (P = 0.0003), serum calcium (P = 0.0048), and tumor diameter (P = 0.0002) were significantly higher in parathyroid carcinoma than in PA. LMR showed a significant decrease in parathyroid carcinoma (P = 0.0062). In multivariate analysis, LMR and tumor length diameter were independent predictors. In the receiver operating characteristics analysis, the cut-off values for LMR and tumor length diameter were 4.85 and 28.0 mm, respectively, for parathyroid cancer prediction. When the two extracted factors were stratified by the number of factors held, the predictive ability improved as the number of factors increased.
Conclusion: In the preoperative evaluation, a combination of tumor length diameter of more than 28 mm and LMR of less than 4.85 was considered to have a high probability of cancer. |
| first_indexed | 2024-04-14T05:06:11Z |
| format | Article |
| id | doaj.art-33fc9420ef97426c924c4bdbeb40c1d5 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-14T05:06:11Z |
| publishDate | 2022-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-33fc9420ef97426c924c4bdbeb40c1d52022-12-22T02:10:41ZengBioscientificaEndocrine Connections2049-36142022-07-0111718https://doi.org/10.1530/EC-22-0062Preoperative inflammatory markers for predicting parathyroid carcinomaKeiko Ohkuwa0Kiminori Sugino1Ryohei Katoh2Mitsuji Nagahama3Wataru Kitagawa4Kenichi Matsuzu5Akifumi Suzuki6Chisato Tomoda7Kiyomi Hames8Junko Akaishi9Chie Masaki10Kana Yoshioka11Koichi Ito12Department of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Pathology, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanDepartment of Surgery, Ito Hospital, Tokyo, JapanObjective: Parathyroid carcinoma is a rare tumor among parathyroid tumors. Aspiration cytology and needle biopsy are generally not recommended for diagnostic purposes because they cause dissemination. Therefore, it is commonly diagnosed by postoperative histopathological examination. In this study, we investigated whether preoperative inflammatory markers can be used as predictors of cancer in patients with primary hyperparathyroidism. Design: This was a retrospective study. Methods: Thirty-six cases of parathyroid carcinoma and 50 cases of parathyroid adenoma (PA) operated with the diagnosis of primary hyperparathyroidism and confirmed histopathologically at Ito Hospital were included in this study. Preoperative clinical characteristics and inflammatory markers (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio (LMR)) were compared and their values in preoperative prediction were evaluated and analyzed. Results: Preoperative intact-parathyroid hormone (P = 0.0003), serum calcium (P = 0.0048), and tumor diameter (P = 0.0002) were significantly higher in parathyroid carcinoma than in PA. LMR showed a significant decrease in parathyroid carcinoma (P = 0.0062). In multivariate analysis, LMR and tumor length diameter were independent predictors. In the receiver operating characteristics analysis, the cut-off values for LMR and tumor length diameter were 4.85 and 28.0 mm, respectively, for parathyroid cancer prediction. When the two extracted factors were stratified by the number of factors held, the predictive ability improved as the number of factors increased. Conclusion: In the preoperative evaluation, a combination of tumor length diameter of more than 28 mm and LMR of less than 4.85 was considered to have a high probability of cancer.https://ec.bioscientifica.com/view/journals/ec/11/7/EC-22-0062.xmllymphocyte-to-monocyte ratiotumor sizeparathyroid carcinomapreoperative prediction |
| spellingShingle | Keiko Ohkuwa Kiminori Sugino Ryohei Katoh Mitsuji Nagahama Wataru Kitagawa Kenichi Matsuzu Akifumi Suzuki Chisato Tomoda Kiyomi Hames Junko Akaishi Chie Masaki Kana Yoshioka Koichi Ito Preoperative inflammatory markers for predicting parathyroid carcinoma Endocrine Connections lymphocyte-to-monocyte ratio tumor size parathyroid carcinoma preoperative prediction |
| title | Preoperative inflammatory markers for predicting parathyroid carcinoma |
| title_full | Preoperative inflammatory markers for predicting parathyroid carcinoma |
| title_fullStr | Preoperative inflammatory markers for predicting parathyroid carcinoma |
| title_full_unstemmed | Preoperative inflammatory markers for predicting parathyroid carcinoma |
| title_short | Preoperative inflammatory markers for predicting parathyroid carcinoma |
| title_sort | preoperative inflammatory markers for predicting parathyroid carcinoma |
| topic | lymphocyte-to-monocyte ratio tumor size parathyroid carcinoma preoperative prediction |
| url | https://ec.bioscientifica.com/view/journals/ec/11/7/EC-22-0062.xml |
| work_keys_str_mv | AT keikoohkuwa preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT kiminorisugino preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT ryoheikatoh preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT mitsujinagahama preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT watarukitagawa preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT kenichimatsuzu preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT akifumisuzuki preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT chisatotomoda preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT kiyomihames preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT junkoakaishi preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT chiemasaki preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT kanayoshioka preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma AT koichiito preoperativeinflammatorymarkersforpredictingparathyroidcarcinoma |