Investigation of the Relationship between Apolipoprotein E Alleles and Serum Lipids in Alzheimer’s Disease: A Meta-Analysis
Prior studies have yielded mixed findings concerning the association between apolipoprotein E(<i>APOE</i>)-<i>ε4</i> and serum lipids in patients with Alzheimer’s disease (AD) and healthy individuals. Some studies suggested a relationship between <i>APOEε4</i> and...
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MDPI AG
2023-11-01
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| author | Huaxue Xu Jiajia Fu Risna Begam Mohammed Nazar Jing Yang Sihui Chen Yan Huang Ting Bao Xueping Chen |
| author_facet | Huaxue Xu Jiajia Fu Risna Begam Mohammed Nazar Jing Yang Sihui Chen Yan Huang Ting Bao Xueping Chen |
| author_sort | Huaxue Xu |
| collection | DOAJ |
| description | Prior studies have yielded mixed findings concerning the association between apolipoprotein E(<i>APOE</i>)-<i>ε4</i> and serum lipids in patients with Alzheimer’s disease (AD) and healthy individuals. Some studies suggested a relationship between <i>APOEε4</i> and serum lipids in patients with AD and healthy individuals, whereas others proposed that the <i>APOEε4</i> allele affects lipids only in patients with AD. Our study aimed to investigate whether <i>APOE</i> alleles have a distinct impact on lipids in AD. We conducted a comprehensive search of the PubMed and Embase databases for all related studies that investigate <i>APOE</i> and serum lipids of AD from the inception to 30 May 2022. Elevated total cholesterol (TC) and low-density lipoprotein (LDL) levels were found in <i>APOEε4</i> allele carriers compared with non-carriers. No significant differences were found for high-density lipoprotein (HDL) and triglyceride (TG) levels in <i>APOEε4</i> allele carriers compared to non-carriers. Notably, elevated TC and LDL levels showed considerable heterogeneity between patients with AD and healthy controls. A network meta-analysis did not find a distinct effect of carrying one or two <i>APOEε4</i> alleles on lipid profiles. Higher TC and LDL levels were found in <i>APOEε4</i> allele carriers compared with non-carriers, and the difference was more significant in patients with AD than in healthy controls. |
| first_indexed | 2024-03-09T16:58:25Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T16:58:25Z |
| publishDate | 2023-11-01 |
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| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-33fd6e68646349319d5be3badddab9c22023-11-24T14:32:43ZengMDPI AGBrain Sciences2076-34252023-11-011311155410.3390/brainsci13111554Investigation of the Relationship between Apolipoprotein E Alleles and Serum Lipids in Alzheimer’s Disease: A Meta-AnalysisHuaxue Xu0Jiajia Fu1Risna Begam Mohammed Nazar2Jing Yang3Sihui Chen4Yan Huang5Ting Bao6Xueping Chen7Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, ChinaManagement Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaManagement Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, ChinaPrior studies have yielded mixed findings concerning the association between apolipoprotein E(<i>APOE</i>)-<i>ε4</i> and serum lipids in patients with Alzheimer’s disease (AD) and healthy individuals. Some studies suggested a relationship between <i>APOEε4</i> and serum lipids in patients with AD and healthy individuals, whereas others proposed that the <i>APOEε4</i> allele affects lipids only in patients with AD. Our study aimed to investigate whether <i>APOE</i> alleles have a distinct impact on lipids in AD. We conducted a comprehensive search of the PubMed and Embase databases for all related studies that investigate <i>APOE</i> and serum lipids of AD from the inception to 30 May 2022. Elevated total cholesterol (TC) and low-density lipoprotein (LDL) levels were found in <i>APOEε4</i> allele carriers compared with non-carriers. No significant differences were found for high-density lipoprotein (HDL) and triglyceride (TG) levels in <i>APOEε4</i> allele carriers compared to non-carriers. Notably, elevated TC and LDL levels showed considerable heterogeneity between patients with AD and healthy controls. A network meta-analysis did not find a distinct effect of carrying one or two <i>APOEε4</i> alleles on lipid profiles. Higher TC and LDL levels were found in <i>APOEε4</i> allele carriers compared with non-carriers, and the difference was more significant in patients with AD than in healthy controls.https://www.mdpi.com/2076-3425/13/11/1554apolipoprotein Eserum lipidsAlzheimer’s diseasemeta-analysis |
| spellingShingle | Huaxue Xu Jiajia Fu Risna Begam Mohammed Nazar Jing Yang Sihui Chen Yan Huang Ting Bao Xueping Chen Investigation of the Relationship between Apolipoprotein E Alleles and Serum Lipids in Alzheimer’s Disease: A Meta-Analysis Brain Sciences apolipoprotein E serum lipids Alzheimer’s disease meta-analysis |
| title | Investigation of the Relationship between Apolipoprotein E Alleles and Serum Lipids in Alzheimer’s Disease: A Meta-Analysis |
| title_full | Investigation of the Relationship between Apolipoprotein E Alleles and Serum Lipids in Alzheimer’s Disease: A Meta-Analysis |
| title_fullStr | Investigation of the Relationship between Apolipoprotein E Alleles and Serum Lipids in Alzheimer’s Disease: A Meta-Analysis |
| title_full_unstemmed | Investigation of the Relationship between Apolipoprotein E Alleles and Serum Lipids in Alzheimer’s Disease: A Meta-Analysis |
| title_short | Investigation of the Relationship between Apolipoprotein E Alleles and Serum Lipids in Alzheimer’s Disease: A Meta-Analysis |
| title_sort | investigation of the relationship between apolipoprotein e alleles and serum lipids in alzheimer s disease a meta analysis |
| topic | apolipoprotein E serum lipids Alzheimer’s disease meta-analysis |
| url | https://www.mdpi.com/2076-3425/13/11/1554 |
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