The impact of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis: a clinical study
Background: Previous studies had shown that major uterine wall resection and reconstruction of the uterus (MURU) was safe and effective in the treatment of adenomyosis. However, MURU results in loss of a significant amount of myometrial and some endometrial tissues, which may have an impact on uteri...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/48/1/10.31083/j.ceog.2021.01.5495 |
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| author | Yan-Bing Xiao Meng Mou Heng-Fang Gu Hui-Xing Li Meng-Yuan You Zhi-Gang Liang Lei Han |
| author_facet | Yan-Bing Xiao Meng Mou Heng-Fang Gu Hui-Xing Li Meng-Yuan You Zhi-Gang Liang Lei Han |
| author_sort | Yan-Bing Xiao |
| collection | DOAJ |
| description | Background: Previous studies had shown that major uterine wall resection and reconstruction of the uterus (MURU) was safe and effective in the treatment of adenomyosis. However, MURU results in loss of a significant amount of myometrial and some endometrial tissues, which may have an impact on uterine hemodynamics and ovarian function. Therefore, it is necessary to study the changes of uterine hemodynamics and ovarian function in patients after MURU, in order to provide an evidence-base for its clinical application. Objective: To explore the effects of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis. Study design: The maximum thickness of unilateral uterine muscle wall or the maximum diameters of adenomyosis focus were measured by ultrasonography. Patients with adenomyosis were divided into three groups: mild, moderate or severe. Fifty cases of adenomyosis without fertility requirement were treated with MURU (observation group), and levonorgestrel-releasing system (LNG-IUS) was placed in uterine cavity during the operation. Fifty patients with intramural myoma of the uterus were selected for hysteromyomectomy (control group). The changes of arterial pulsation index (PI) and resistance index (RI) of uterine artery, as well as antral follicle count (AFC) and serum antimullerian hormone (AMH) were observed before operation and 1 month, 3 months, 6 months, 12 months and 18 months post-operation. Results: No complications were observed in both groups, no significant difference in uterine hemodynamics and ovarian function were found between the two groups (P > 0.05). During intragroup comparison, there were no significant changes in PI and RI before and after operation in the two groups, and no significant changes in AFC and AMH were detected in both groups before and after operation (P > 0.05). Conclusions: MURU did not significantly affect the uterine hemodynamics and ovarian function in patients with adenomyosis, but the long-term effects need to be further investigated. |
| first_indexed | 2024-12-12T05:21:20Z |
| format | Article |
| id | doaj.art-33fe272a57de4b05991fef952ab657a6 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T05:21:20Z |
| publishDate | 2021-02-01 |
| publisher | IMR Press |
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| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-33fe272a57de4b05991fef952ab657a62022-12-22T00:36:37ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-02-0148113213710.31083/j.ceog.2021.01.5495S0390-6663(21)00057-9The impact of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis: a clinical studyYan-Bing Xiao0Meng Mou1Heng-Fang Gu2Hui-Xing Li3Meng-Yuan You4Zhi-Gang Liang5Lei Han6Maternal and Child Health Hospital Affiliated to Zunyi Medical University, 563000 Guizhou Province, P. R. ChinaMaternal and Child Health Hospital Affiliated to Zunyi Medical University, 563000 Guizhou Province, P. R. ChinaMaternal and Child Health Hospital Affiliated to Zunyi Medical University, 563000 Guizhou Province, P. R. ChinaMaternal and Child Health Hospital Affiliated to Zunyi Medical University, 563000 Guizhou Province, P. R. ChinaMaternal and Child Health Hospital Affiliated to Zunyi Medical University, 563000 Guizhou Province, P. R. ChinaMaternal and Child Health Hospital Affiliated to Zunyi Medical University, 563000 Guizhou Province, P. R. ChinaMaternal and Child Health Hospital Affiliated to Zunyi Medical University, 563000 Guizhou Province, P. R. ChinaBackground: Previous studies had shown that major uterine wall resection and reconstruction of the uterus (MURU) was safe and effective in the treatment of adenomyosis. However, MURU results in loss of a significant amount of myometrial and some endometrial tissues, which may have an impact on uterine hemodynamics and ovarian function. Therefore, it is necessary to study the changes of uterine hemodynamics and ovarian function in patients after MURU, in order to provide an evidence-base for its clinical application. Objective: To explore the effects of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis. Study design: The maximum thickness of unilateral uterine muscle wall or the maximum diameters of adenomyosis focus were measured by ultrasonography. Patients with adenomyosis were divided into three groups: mild, moderate or severe. Fifty cases of adenomyosis without fertility requirement were treated with MURU (observation group), and levonorgestrel-releasing system (LNG-IUS) was placed in uterine cavity during the operation. Fifty patients with intramural myoma of the uterus were selected for hysteromyomectomy (control group). The changes of arterial pulsation index (PI) and resistance index (RI) of uterine artery, as well as antral follicle count (AFC) and serum antimullerian hormone (AMH) were observed before operation and 1 month, 3 months, 6 months, 12 months and 18 months post-operation. Results: No complications were observed in both groups, no significant difference in uterine hemodynamics and ovarian function were found between the two groups (P > 0.05). During intragroup comparison, there were no significant changes in PI and RI before and after operation in the two groups, and no significant changes in AFC and AMH were detected in both groups before and after operation (P > 0.05). Conclusions: MURU did not significantly affect the uterine hemodynamics and ovarian function in patients with adenomyosis, but the long-term effects need to be further investigated.https://www.imrpress.com/journal/CEOG/48/1/10.31083/j.ceog.2021.01.5495muruadenomyosisuterine hemodynamicsovarian function |
| spellingShingle | Yan-Bing Xiao Meng Mou Heng-Fang Gu Hui-Xing Li Meng-Yuan You Zhi-Gang Liang Lei Han The impact of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis: a clinical study Clinical and Experimental Obstetrics & Gynecology muru adenomyosis uterine hemodynamics ovarian function |
| title | The impact of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis: a clinical study |
| title_full | The impact of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis: a clinical study |
| title_fullStr | The impact of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis: a clinical study |
| title_full_unstemmed | The impact of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis: a clinical study |
| title_short | The impact of major uterine wall resection and reconstruction of the uterus (MURU) on uterine hemodynamics and ovarian function in patients with adenomyosis: a clinical study |
| title_sort | impact of major uterine wall resection and reconstruction of the uterus muru on uterine hemodynamics and ovarian function in patients with adenomyosis a clinical study |
| topic | muru adenomyosis uterine hemodynamics ovarian function |
| url | https://www.imrpress.com/journal/CEOG/48/1/10.31083/j.ceog.2021.01.5495 |
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