Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity
Acetaminophen (APAP) is the most common prescription medicine around the world for the treatment of pain and fever and is considered to be a safe drug at its therapeutic dose. However, a single overdose or frequent use of APAP can cause severe acute liver injury. APAP hepatotoxicity is a prevalent c...
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MDPI AG
2022-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/7/1498 |
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| author | Saikat Dewanjee Tarun K. Dua Paramita Paul Abhijit Dey Jayalakshmi Vallamkondu Sonalinandini Samanta Ramesh Kandimalla Vincenzo De Feo |
| author_facet | Saikat Dewanjee Tarun K. Dua Paramita Paul Abhijit Dey Jayalakshmi Vallamkondu Sonalinandini Samanta Ramesh Kandimalla Vincenzo De Feo |
| author_sort | Saikat Dewanjee |
| collection | DOAJ |
| description | Acetaminophen (APAP) is the most common prescription medicine around the world for the treatment of pain and fever and is considered to be a safe drug at its therapeutic dose. However, a single overdose or frequent use of APAP can cause severe acute liver injury. APAP hepatotoxicity is a prevalent cause of acute liver disease around the world and the lack of suitable treatment makes it a serious problem. In recent years, there has been a surge in interest in using probiotics and probiotic-derived products, known as postbiotics, as health and disease negotiators. A growing body of evidence revealed that they can be equally effective against APAP hepatotoxicity. Different probiotic bacteria were found to be pre-clinically effective against APAP hepatotoxicity. Different postbiotics have also shown exciting results in preclinical models of APAP hepatotoxicity. This review summarized the protective roles and mechanisms of the different probiotic bacteria and postbiotics against APAP hepatotoxicity, with critical discussion. A brief discussion on potential novel probiotics and postbiotics for oxidative liver injury was also included. This review was written in an attempt to pique the interest of researchers in developing a safe therapeutic option against oxidative liver damage using probiotics and/or postbiotics as dietary supplements. |
| first_indexed | 2024-03-09T03:40:09Z |
| format | Article |
| id | doaj.art-33fed965f75549f78ed87a71825b6652 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T03:40:09Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-33fed965f75549f78ed87a71825b66522023-12-03T14:41:07ZengMDPI AGBiomedicines2227-90592022-06-01107149810.3390/biomedicines10071498Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced HepatotoxicitySaikat Dewanjee0Tarun K. Dua1Paramita Paul2Abhijit Dey3Jayalakshmi Vallamkondu4Sonalinandini Samanta5Ramesh Kandimalla6Vincenzo De Feo7Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaDepartment of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur 734013, IndiaDepartment of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur 734013, IndiaDepartment of Life Sciences, Presidency University, Kolkata 700073, IndiaDepartment of Physics, National Institute of Technology, Warangal 506004, IndiaDepartment of Dermatology (Skin & Venereology), Employee’s State Insurance Corporation Medical College & Hospital, Patna 801103, IndiaDepartment of Biochemistry, Kakatiya Medical College, Warangal 506007, IndiaDepartment of Pharmacy, University of Salerno, 84084 Fisciano, ItalyAcetaminophen (APAP) is the most common prescription medicine around the world for the treatment of pain and fever and is considered to be a safe drug at its therapeutic dose. However, a single overdose or frequent use of APAP can cause severe acute liver injury. APAP hepatotoxicity is a prevalent cause of acute liver disease around the world and the lack of suitable treatment makes it a serious problem. In recent years, there has been a surge in interest in using probiotics and probiotic-derived products, known as postbiotics, as health and disease negotiators. A growing body of evidence revealed that they can be equally effective against APAP hepatotoxicity. Different probiotic bacteria were found to be pre-clinically effective against APAP hepatotoxicity. Different postbiotics have also shown exciting results in preclinical models of APAP hepatotoxicity. This review summarized the protective roles and mechanisms of the different probiotic bacteria and postbiotics against APAP hepatotoxicity, with critical discussion. A brief discussion on potential novel probiotics and postbiotics for oxidative liver injury was also included. This review was written in an attempt to pique the interest of researchers in developing a safe therapeutic option against oxidative liver damage using probiotics and/or postbiotics as dietary supplements.https://www.mdpi.com/2227-9059/10/7/1498acetaminophenhepatotoxicitynutraceuticalspostbioticsprobiotics |
| spellingShingle | Saikat Dewanjee Tarun K. Dua Paramita Paul Abhijit Dey Jayalakshmi Vallamkondu Sonalinandini Samanta Ramesh Kandimalla Vincenzo De Feo Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity Biomedicines acetaminophen hepatotoxicity nutraceuticals postbiotics probiotics |
| title | Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity |
| title_full | Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity |
| title_fullStr | Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity |
| title_full_unstemmed | Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity |
| title_short | Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity |
| title_sort | probiotics evolving as a potential therapeutic option against acetaminophen induced hepatotoxicity |
| topic | acetaminophen hepatotoxicity nutraceuticals postbiotics probiotics |
| url | https://www.mdpi.com/2227-9059/10/7/1498 |
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