Giant cell myocarditis with prolonged cardiac standstill after drug‐induced hypersensitivity syndrome: a case report
Abstract Giant cell myocarditis (GCM) is a rare but fatal disease that can lead to cardiac failure. Survival with a cardiac standstill requires mechanical circulatory support or a biventricular assist device (BiVAD) and prolonged survival is extremely rare. Drug‐induced hypersensitivity syndrome (DI...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-04-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.14678 |
| _version_ | 1797242804510916608 |
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| author | Ryohei Ono Hiroki Kohno Sae Kaminota Kaoruko Aoki Hirotoshi Kato Togo Iwahana Takanori Aihara Masayuki Ota Goro Matsumiya Yoshio Kobayashi |
| author_facet | Ryohei Ono Hiroki Kohno Sae Kaminota Kaoruko Aoki Hirotoshi Kato Togo Iwahana Takanori Aihara Masayuki Ota Goro Matsumiya Yoshio Kobayashi |
| author_sort | Ryohei Ono |
| collection | DOAJ |
| description | Abstract Giant cell myocarditis (GCM) is a rare but fatal disease that can lead to cardiac failure. Survival with a cardiac standstill requires mechanical circulatory support or a biventricular assist device (BiVAD) and prolonged survival is extremely rare. Drug‐induced hypersensitivity syndrome (DIHS) is a severe cutaneous adverse reaction. Some cases of DIHS are reportedly associated with the onset of GCM. We present a case of a 28‐year‐old woman who developed GCM during steroid tapering after DIHS. She went into continuous cardiac standstill but survived for 74 days under BiVAD support. Our case is noteworthy because the histopathologic specimens obtained on three occasions contributed to the diagnosis of this particular condition over time. We also reviewed previous literature on concomitant cases of GCM and DIHS. We found that two are potentially associated and most cases of GCM occur within 3 months of DIHS during steroid tapering. |
| first_indexed | 2024-04-24T18:45:02Z |
| format | Article |
| id | doaj.art-33ff91c739a045028ce842873e51c37e |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-24T18:45:02Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-33ff91c739a045028ce842873e51c37e2024-03-27T06:48:03ZengWileyESC Heart Failure2055-58222024-04-0111280581010.1002/ehf2.14678Giant cell myocarditis with prolonged cardiac standstill after drug‐induced hypersensitivity syndrome: a case reportRyohei Ono0Hiroki Kohno1Sae Kaminota2Kaoruko Aoki3Hirotoshi Kato4Togo Iwahana5Takanori Aihara6Masayuki Ota7Goro Matsumiya8Yoshio Kobayashi9Department of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba JapanDepartment of Cardiovascular Surgery Chiba University Graduate School of Medicine Chiba JapanChiba University School of Medicine Chiba JapanDepartment of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba JapanDepartment of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba JapanDepartment of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba JapanDepartment of Pathology Chiba University Hospital Chiba JapanDepartment of Diagnostic Pathology, Graduate School of Medicine Chiba University Chiba JapanDepartment of Cardiovascular Surgery Chiba University Graduate School of Medicine Chiba JapanDepartment of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba JapanAbstract Giant cell myocarditis (GCM) is a rare but fatal disease that can lead to cardiac failure. Survival with a cardiac standstill requires mechanical circulatory support or a biventricular assist device (BiVAD) and prolonged survival is extremely rare. Drug‐induced hypersensitivity syndrome (DIHS) is a severe cutaneous adverse reaction. Some cases of DIHS are reportedly associated with the onset of GCM. We present a case of a 28‐year‐old woman who developed GCM during steroid tapering after DIHS. She went into continuous cardiac standstill but survived for 74 days under BiVAD support. Our case is noteworthy because the histopathologic specimens obtained on three occasions contributed to the diagnosis of this particular condition over time. We also reviewed previous literature on concomitant cases of GCM and DIHS. We found that two are potentially associated and most cases of GCM occur within 3 months of DIHS during steroid tapering.https://doi.org/10.1002/ehf2.14678Biventricular assist deviceCardiac arrestCardiac standstillDrug‐induced hypersensitivity syndromeGiant cell myocarditisReview |
| spellingShingle | Ryohei Ono Hiroki Kohno Sae Kaminota Kaoruko Aoki Hirotoshi Kato Togo Iwahana Takanori Aihara Masayuki Ota Goro Matsumiya Yoshio Kobayashi Giant cell myocarditis with prolonged cardiac standstill after drug‐induced hypersensitivity syndrome: a case report ESC Heart Failure Biventricular assist device Cardiac arrest Cardiac standstill Drug‐induced hypersensitivity syndrome Giant cell myocarditis Review |
| title | Giant cell myocarditis with prolonged cardiac standstill after drug‐induced hypersensitivity syndrome: a case report |
| title_full | Giant cell myocarditis with prolonged cardiac standstill after drug‐induced hypersensitivity syndrome: a case report |
| title_fullStr | Giant cell myocarditis with prolonged cardiac standstill after drug‐induced hypersensitivity syndrome: a case report |
| title_full_unstemmed | Giant cell myocarditis with prolonged cardiac standstill after drug‐induced hypersensitivity syndrome: a case report |
| title_short | Giant cell myocarditis with prolonged cardiac standstill after drug‐induced hypersensitivity syndrome: a case report |
| title_sort | giant cell myocarditis with prolonged cardiac standstill after drug induced hypersensitivity syndrome a case report |
| topic | Biventricular assist device Cardiac arrest Cardiac standstill Drug‐induced hypersensitivity syndrome Giant cell myocarditis Review |
| url | https://doi.org/10.1002/ehf2.14678 |
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