Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterization and RALA complexation

Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterization and RALA complexation

DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited immunogenicity in vivo due to the absence of a suitable delivery system which can protect DNA from degradation and improve transfection efficien...

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Bibliographic Details
Main Authors: Grace Cole, Joanne McCaffrey, Ahlam A. Ali, John W. McBride, Cian M. McCrudden, Eva M. Vincente-Perez, Ryan F. Donnelly, Helen O. McCarthy
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
dna vaccine
microneedle
nanoparticle
pva
rala
Online Access:http://dx.doi.org/10.1080/21645515.2016.1248008

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