Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series
Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) refer to heterogenous rare neoplasms constituted of at least a neuroendocrine population—either well-differentiated, or more frequently poorly differentiated—and a non-neuroendocrine population, both accounting for at least 30% of the whole...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Healthcare |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9032/10/4/708 |
| _version_ | 1797434606920663040 |
|---|---|
| author | Luigi Pio Guerrera Gabriella Suarato Rossella Napolitano Alessandra Perrone Vincenza Caputo Anna Ventriglia Giulia Martini Carminia Maria Della Corte Michele Orditura Erika Martinelli Fortunato Ciardiello Marco Montella Renato Franco Teresa Troiani Stefania Napolitano |
| author_facet | Luigi Pio Guerrera Gabriella Suarato Rossella Napolitano Alessandra Perrone Vincenza Caputo Anna Ventriglia Giulia Martini Carminia Maria Della Corte Michele Orditura Erika Martinelli Fortunato Ciardiello Marco Montella Renato Franco Teresa Troiani Stefania Napolitano |
| author_sort | Luigi Pio Guerrera |
| collection | DOAJ |
| description | Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) refer to heterogenous rare neoplasms constituted of at least a neuroendocrine population—either well-differentiated, or more frequently poorly differentiated—and a non-neuroendocrine population, both accounting for at least 30% of the whole tumor mass. Several studies recently focused on the key genetic and epigenetic changes underlying MiNENs to better understand how they develop, and explore biological similarities among the two components and their pure counterparts. However, their molecular landscape still remains poorly understood. NGS may represent a useful tool to study this orphan disease by detecting the main genetic alterations and possible therapeutic targets. NGS analysis on tissue and/or blood samples through the Foundation One (F1) platform was performed on consecutive samples collected from four patients diagnosed with MiNENs of the gastroenteric tract. Several genetic alterations were shared among samples from the same patients, thus suggesting a common origin between them, although morphology sometimes changed at histopathological evaluation. Common molecular alterations among samples from different patients that had not been previously described to our knowledge were also detected. Finally, it is of the utmost importance to clarify if the maintenance of the 30% cut-off is still essential in defining MiNENs and really manages to include all of the mixed neoplasms. |
| first_indexed | 2024-03-09T10:34:54Z |
| format | Article |
| id | doaj.art-34002e91914a42f1bf3c341fda7a6b1b |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-09T10:34:54Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-34002e91914a42f1bf3c341fda7a6b1b2023-12-01T20:59:22ZengMDPI AGHealthcare2227-90322022-04-0110470810.3390/healthcare10040708Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case SeriesLuigi Pio Guerrera0Gabriella Suarato1Rossella Napolitano2Alessandra Perrone3Vincenza Caputo4Anna Ventriglia5Giulia Martini6Carminia Maria Della Corte7Michele Orditura8Erika Martinelli9Fortunato Ciardiello10Marco Montella11Renato Franco12Teresa Troiani13Stefania Napolitano14Medical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyPathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Napoli, ItalyPathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMedical Oncology, Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Napoli, ItalyMixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) refer to heterogenous rare neoplasms constituted of at least a neuroendocrine population—either well-differentiated, or more frequently poorly differentiated—and a non-neuroendocrine population, both accounting for at least 30% of the whole tumor mass. Several studies recently focused on the key genetic and epigenetic changes underlying MiNENs to better understand how they develop, and explore biological similarities among the two components and their pure counterparts. However, their molecular landscape still remains poorly understood. NGS may represent a useful tool to study this orphan disease by detecting the main genetic alterations and possible therapeutic targets. NGS analysis on tissue and/or blood samples through the Foundation One (F1) platform was performed on consecutive samples collected from four patients diagnosed with MiNENs of the gastroenteric tract. Several genetic alterations were shared among samples from the same patients, thus suggesting a common origin between them, although morphology sometimes changed at histopathological evaluation. Common molecular alterations among samples from different patients that had not been previously described to our knowledge were also detected. Finally, it is of the utmost importance to clarify if the maintenance of the 30% cut-off is still essential in defining MiNENs and really manages to include all of the mixed neoplasms.https://www.mdpi.com/2227-9032/10/4/708MiNENsmixed neuroendocrine/non-neuroendocrine neoplasmsgastrointestinal tumorsNGS analysisFoundation One (F1) |
| spellingShingle | Luigi Pio Guerrera Gabriella Suarato Rossella Napolitano Alessandra Perrone Vincenza Caputo Anna Ventriglia Giulia Martini Carminia Maria Della Corte Michele Orditura Erika Martinelli Fortunato Ciardiello Marco Montella Renato Franco Teresa Troiani Stefania Napolitano Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series Healthcare MiNENs mixed neuroendocrine/non-neuroendocrine neoplasms gastrointestinal tumors NGS analysis Foundation One (F1) |
| title | Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series |
| title_full | Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series |
| title_fullStr | Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series |
| title_full_unstemmed | Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series |
| title_short | Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series |
| title_sort | mixed neuroendocrine non neuroendocrine neoplasms of the gastrointestinal tract a case series |
| topic | MiNENs mixed neuroendocrine/non-neuroendocrine neoplasms gastrointestinal tumors NGS analysis Foundation One (F1) |
| url | https://www.mdpi.com/2227-9032/10/4/708 |
| work_keys_str_mv | AT luigipioguerrera mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT gabriellasuarato mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT rossellanapolitano mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT alessandraperrone mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT vincenzacaputo mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT annaventriglia mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT giuliamartini mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT carminiamariadellacorte mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT micheleorditura mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT erikamartinelli mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT fortunatociardiello mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT marcomontella mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT renatofranco mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT teresatroiani mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries AT stefanianapolitano mixedneuroendocrinenonneuroendocrineneoplasmsofthegastrointestinaltractacaseseries |