Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response

Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response

Differences in hydroxyurea response in sickle cell anemia may arise due to a series of factors with genetic factors appearing to be predominant. This study aims to investigate the effects of single nucleotide polymorphisms in genes encoding drug-metabolizing enzymes and solute carriers on hydroxyure...

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Bibliographic Details
Main Authors: Sètondji Cocou Modeste Alexandre Yahouédéhou, Joelma Santana dos Santos Neres, Caroline Conceição da Guarda, Suellen Pinheiro Carvalho, Rayra Pereira Santiago, Camylla Vilas Boas Figueiredo, Luciana Magalhães Fiuza, Uche Samuel Ndidi, Rodrigo Mota de Oliveira, Cleverson Alves Fonseca, Valma Maria Lopes Nascimento, Larissa Carneiro Rocha, Corynne Stéphanie Ahouéfa Adanho, Tiago Santos Carvalho da Rocha, Elisângela Vitória Adorno, Marilda Souza Goncalves
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
sickle cell anemia
hydroxyurea
CYP2D6
CYP3A4
CAT
SLC14A1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.553064/full

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