Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation
As bone biology develops, it is gradually recognized that bone regeneration is a pathophysiological process that requires the simultaneous participation of multiple systems. With the introduction of osteoimmunology, the interplay between the immune system and the musculoskeletal diseases has been th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1023231/full |
| _version_ | 1797990016631177216 |
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| author | Bin Lv Juntao Wu Yuan Xiong Xudong Xie Ze Lin Bobin Mi Guohui Liu |
| author_facet | Bin Lv Juntao Wu Yuan Xiong Xudong Xie Ze Lin Bobin Mi Guohui Liu |
| author_sort | Bin Lv |
| collection | DOAJ |
| description | As bone biology develops, it is gradually recognized that bone regeneration is a pathophysiological process that requires the simultaneous participation of multiple systems. With the introduction of osteoimmunology, the interplay between the immune system and the musculoskeletal diseases has been the conceptual framework for a thorough understanding of both systems and the advancement of osteoimmunomodulaty biomaterials. Various therapeutic strategies which include intervention of the surface characteristics or the local delivery systems with the incorporation of bioactive molecules have been applied to create an ideal bone microenvironment for bone tissue regeneration. Our review systematically summarized the current research that is being undertaken in the field of osteoimmunomodulaty bone biomaterials on a case-by-case basis, aiming to inspire more extensive research and promote clinical conversion. |
| first_indexed | 2024-04-11T08:28:45Z |
| format | Article |
| id | doaj.art-3401f132ad1547b0a4e14507d4852d1f |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T08:28:45Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-3401f132ad1547b0a4e14507d4852d1f2022-12-22T04:34:36ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-11-011010.3389/fbioe.2022.10232311023231Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulationBin LvJuntao WuYuan XiongXudong XieZe LinBobin MiGuohui LiuAs bone biology develops, it is gradually recognized that bone regeneration is a pathophysiological process that requires the simultaneous participation of multiple systems. With the introduction of osteoimmunology, the interplay between the immune system and the musculoskeletal diseases has been the conceptual framework for a thorough understanding of both systems and the advancement of osteoimmunomodulaty biomaterials. Various therapeutic strategies which include intervention of the surface characteristics or the local delivery systems with the incorporation of bioactive molecules have been applied to create an ideal bone microenvironment for bone tissue regeneration. Our review systematically summarized the current research that is being undertaken in the field of osteoimmunomodulaty bone biomaterials on a case-by-case basis, aiming to inspire more extensive research and promote clinical conversion.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1023231/fullbiomaterialsbone tissue engineeringosteoimmunomodulationbone regenerationdrug delivery |
| spellingShingle | Bin Lv Juntao Wu Yuan Xiong Xudong Xie Ze Lin Bobin Mi Guohui Liu Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation Frontiers in Bioengineering and Biotechnology biomaterials bone tissue engineering osteoimmunomodulation bone regeneration drug delivery |
| title | Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation |
| title_full | Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation |
| title_fullStr | Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation |
| title_full_unstemmed | Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation |
| title_short | Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation |
| title_sort | functionalized multidimensional biomaterials for bone microenvironment engineering applications focus on osteoimmunomodulation |
| topic | biomaterials bone tissue engineering osteoimmunomodulation bone regeneration drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1023231/full |
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