The Impact of ETV6-NTRK3 Oncogenic Gene Fusions on Molecular and Signaling Pathway Alterations

The Impact of ETV6-NTRK3 Oncogenic Gene Fusions on Molecular and Signaling Pathway Alterations

Chromosomal translocations creating fusion genes are common cancer drivers. The oncogenic ETV6-NTRK3 (EN) gene fusion joins the sterile alpha domain of the ETV6 transcription factor with the tyrosine kinase domain of the neurotrophin-3 receptor NTRK3. Four EN variants with alternating break points h...

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Bibliographic Details
Main Authors: Matias Kinnunen, Xiaonan Liu, Elina Niemelä, Tiina Öhman, Lisa Gawriyski, Kari Salokas, Salla Keskitalo, Markku Varjosalo
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
ETV6-NTRK3
gene fusion
breakpoint variant
proteomics
interaction analysis
mass spectrometry
Online Access:https://www.mdpi.com/2072-6694/15/17/4246

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