Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening
Background: Mammographic density and family history of breast cancer (FHBC) are well-established independent factors affecting breast cancer risk; however, the association between these two risk factors in premenopausal-screened women remains unclear. The aim of this study is to investigate the rela...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Clinics and Practice |
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| Online Access: | https://www.mdpi.com/2039-7283/14/1/13 |
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| author | Ibrahem Hussain Kanbayti Mayada A. Alzahrani Yara O. Yeslam Noora H. Habib Ibrahim Hadadi Yousef Almaimoni Adnan Alahmadi Ernest U. Ekpo |
| author_facet | Ibrahem Hussain Kanbayti Mayada A. Alzahrani Yara O. Yeslam Noora H. Habib Ibrahim Hadadi Yousef Almaimoni Adnan Alahmadi Ernest U. Ekpo |
| author_sort | Ibrahem Hussain Kanbayti |
| collection | DOAJ |
| description | Background: Mammographic density and family history of breast cancer (FHBC) are well-established independent factors affecting breast cancer risk; however, the association between these two risk factors in premenopausal-screened women remains unclear. The aim of this study is to investigate the relationship between mammographic density and FHBC among Saudi premenopausal-screened women. Methods: A total of 446 eligible participants were included in the study. Mammographic density was assessed qualitatively using the Breast Imaging Reporting and Data System (BIRADS 4th edition). Logistic regression models were built to investigate the relationship between mammographic density and FHBC. Results: Women with a family history of breast cancer demonstrated an 87% greater chance of having dense tissue than women without a family history of breast cancer (95% CI: 1.14–3.08; <i>p =</i> 0.01). Having a positive family history for breast cancer in mothers was significantly associated with dense tissue (adjusted odds ratio (OR): 5.6; 95% CI: 1.3–24.1; <i>p</i> = 0.02). Conclusion: Dense breast tissue in Saudi premenopausal women undergoing screening may be linked to FHBC. If this conclusion is replicated in larger studies, then breast cancer risk prediction models must carefully consider these breast cancer risk factors. |
| first_indexed | 2024-03-07T22:36:21Z |
| format | Article |
| id | doaj.art-34036def84334cf0bd662f13d8a43250 |
| institution | Directory Open Access Journal |
| issn | 2039-7283 |
| language | English |
| last_indexed | 2024-03-07T22:36:21Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-34036def84334cf0bd662f13d8a432502024-02-23T15:12:45ZengMDPI AGClinics and Practice2039-72832024-01-0114116417210.3390/clinpract14010013Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography ScreeningIbrahem Hussain Kanbayti0Mayada A. Alzahrani1Yara O. Yeslam2Noora H. Habib3Ibrahim Hadadi4Yousef Almaimoni5Adnan Alahmadi6Ernest U. Ekpo7Radiologic Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaRadiologic Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaRadiologic Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaRadiologic Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Radiological Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi ArabiaRadiologic Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaRadiologic Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaMedical Image Optimization and Perception Group (MIOPeG), Faculty of Medicine and Health, The University of Sydney, Campus C4 75 East Street, Sydney, NSW 2141, AustraliaBackground: Mammographic density and family history of breast cancer (FHBC) are well-established independent factors affecting breast cancer risk; however, the association between these two risk factors in premenopausal-screened women remains unclear. The aim of this study is to investigate the relationship between mammographic density and FHBC among Saudi premenopausal-screened women. Methods: A total of 446 eligible participants were included in the study. Mammographic density was assessed qualitatively using the Breast Imaging Reporting and Data System (BIRADS 4th edition). Logistic regression models were built to investigate the relationship between mammographic density and FHBC. Results: Women with a family history of breast cancer demonstrated an 87% greater chance of having dense tissue than women without a family history of breast cancer (95% CI: 1.14–3.08; <i>p =</i> 0.01). Having a positive family history for breast cancer in mothers was significantly associated with dense tissue (adjusted odds ratio (OR): 5.6; 95% CI: 1.3–24.1; <i>p</i> = 0.02). Conclusion: Dense breast tissue in Saudi premenopausal women undergoing screening may be linked to FHBC. If this conclusion is replicated in larger studies, then breast cancer risk prediction models must carefully consider these breast cancer risk factors.https://www.mdpi.com/2039-7283/14/1/13mammographic densityfamily history of breast cancerpremenopausal women |
| spellingShingle | Ibrahem Hussain Kanbayti Mayada A. Alzahrani Yara O. Yeslam Noora H. Habib Ibrahim Hadadi Yousef Almaimoni Adnan Alahmadi Ernest U. Ekpo Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening Clinics and Practice mammographic density family history of breast cancer premenopausal women |
| title | Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening |
| title_full | Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening |
| title_fullStr | Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening |
| title_full_unstemmed | Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening |
| title_short | Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening |
| title_sort | association between family history of breast cancer and breast density in saudi premenopausal women participating in mammography screening |
| topic | mammographic density family history of breast cancer premenopausal women |
| url | https://www.mdpi.com/2039-7283/14/1/13 |
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