Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis
Recently, a series of studies explored the correlation between the neutrophil to lymphocyte ratio and the prognosis of lung cancer. However, the current opinion regarding the prognostic role of the neutrophil to lymphocyte ratio in lung cancer is inconsistent. We performed a meta-analysis of publish...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2015-07-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000700524&lng=en&tlng=en |
| _version_ | 1811318907359723520 |
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| author | Yongmei Yin Jun Wang Xuedong Wang Lan Gu Hao Pei Shougang Kuai Yingying Zhang Zhongbo Shang |
| author_facet | Yongmei Yin Jun Wang Xuedong Wang Lan Gu Hao Pei Shougang Kuai Yingying Zhang Zhongbo Shang |
| author_sort | Yongmei Yin |
| collection | DOAJ |
| description | Recently, a series of studies explored the correlation between the neutrophil to lymphocyte ratio and the prognosis of lung cancer. However, the current opinion regarding the prognostic role of the neutrophil to lymphocyte ratio in lung cancer is inconsistent. We performed a meta-analysis of published articles to investigate the prognostic value of the neutrophil to lymphocyte ratio in lung cancer. The hazard ratio (HR) and its 95% confidence interval (CI) were calculated. An elevated neutrophil to lymphocyte ratio predicted worse overall survival, with a pooled HR of 1.243 (95%CI: 1.106-1.397; Pheterogeneity=0.001) from multivariate studies and 1.867 (95%CI: 1.487-2.344; Pheterogeneity=0.047) from univariate studies. Subgroup analysis showed that a high neutrophil to lymphocyte ratio yielded worse overall survival in non-small cell lung cancer (NSCLC) (HR=1.192, 95%CI: 1.061-1.399; Pheterogeneity=0.003) as well as small cell lung cancer (SCLC) (HR=1.550, 95% CI: 1.156-2.077; Pheterogeneity=0.625) in multivariate studies. The synthesized evidence from this meta-analysis of published articles demonstrated that an elevated neutrophil to lymphocyte ratio was a predictor of poor overall survival in patients with lung cancer. |
| first_indexed | 2024-04-13T12:33:24Z |
| format | Article |
| id | doaj.art-3403e8be433244f9bc6b8b5d34907e7b |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T12:33:24Z |
| publishDate | 2015-07-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-3403e8be433244f9bc6b8b5d34907e7b2022-12-22T02:46:44ZengElsevier EspañaClinics1980-53222015-07-0170752453010.6061/clinics/2015(07)10S1807-59322015000700524Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysisYongmei YinJun WangXuedong WangLan GuHao PeiShougang KuaiYingying ZhangZhongbo ShangRecently, a series of studies explored the correlation between the neutrophil to lymphocyte ratio and the prognosis of lung cancer. However, the current opinion regarding the prognostic role of the neutrophil to lymphocyte ratio in lung cancer is inconsistent. We performed a meta-analysis of published articles to investigate the prognostic value of the neutrophil to lymphocyte ratio in lung cancer. The hazard ratio (HR) and its 95% confidence interval (CI) were calculated. An elevated neutrophil to lymphocyte ratio predicted worse overall survival, with a pooled HR of 1.243 (95%CI: 1.106-1.397; Pheterogeneity=0.001) from multivariate studies and 1.867 (95%CI: 1.487-2.344; Pheterogeneity=0.047) from univariate studies. Subgroup analysis showed that a high neutrophil to lymphocyte ratio yielded worse overall survival in non-small cell lung cancer (NSCLC) (HR=1.192, 95%CI: 1.061-1.399; Pheterogeneity=0.003) as well as small cell lung cancer (SCLC) (HR=1.550, 95% CI: 1.156-2.077; Pheterogeneity=0.625) in multivariate studies. The synthesized evidence from this meta-analysis of published articles demonstrated that an elevated neutrophil to lymphocyte ratio was a predictor of poor overall survival in patients with lung cancer.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000700524&lng=en&tlng=enNLRLung CancerOverall SurvivalMeta-Analysis |
| spellingShingle | Yongmei Yin Jun Wang Xuedong Wang Lan Gu Hao Pei Shougang Kuai Yingying Zhang Zhongbo Shang Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis Clinics NLR Lung Cancer Overall Survival Meta-Analysis |
| title | Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis |
| title_full | Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis |
| title_fullStr | Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis |
| title_full_unstemmed | Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis |
| title_short | Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis |
| title_sort | prognostic value of the neutrophil to lymphocyte ratio in lung cancer a meta analysis |
| topic | NLR Lung Cancer Overall Survival Meta-Analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000700524&lng=en&tlng=en |
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