β3 adrenergic agonism: A novel pathway which improves right ventricular‐pulmonary arterial hemodynamics in pulmonary arterial hypertension

β3 adrenergic agonism: A novel pathway which improves right ventricular‐pulmonary arterial hemodynamics in pulmonary arterial hypertension

Abstract Efficacy of therapies that target the downstream nitric oxide (NO) pathway in pulmonary arterial hypertension (PAH) depends on the bioavailability of NO. Reduced NO level in PAH is secondary to “uncoupling” of endothelial nitric oxide synthase (eNOS). Stimulation of β3 adrenergic receptors...

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Bibliographic Details
Main Authors: Keyvan Karimi Galougahi, Yunjia Zhang, Vivian Kienzle, Chia‐Chi Liu, Lake‐Ee Quek, Sanjay Patel, Edmund Lau, Rachael L. Cordina, Gemma A. Figtree, David S. Celermajer
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Physiological Reports
Subjects:
endothelial nitric oxide synthase
pulmonary arterial hypertension
redox signaling
right ventricular hemodynamics
β3 adrenergic receptors
Online Access:https://doi.org/10.14814/phy2.15549

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