Acute Changes in Heart Rate Variability to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial
Background: It is unknown how different types of carbohydrates alter the cardio-autonomic system in healthy individuals. Therefore, the aim of this study was to investigate how heart-rate variability changes to single dose ingestion of glucose, fructose, glucose and fructose, and an artificial sweet...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/11/2/338 |
| _version_ | 1797482525252124672 |
|---|---|
| author | Max Lennart Eckstein Antonia Brockfeld Sandra Haupt Janis Ramon Schierbauer Rebecca Tanja Zimmer Nadine Bianca Wachsmuth Beate Elisabeth Maria Zunner Paul Zimmermann Maximilian Erlmann Barbara Obermayer-Pietsch Felix Aberer Othmar Moser |
| author_facet | Max Lennart Eckstein Antonia Brockfeld Sandra Haupt Janis Ramon Schierbauer Rebecca Tanja Zimmer Nadine Bianca Wachsmuth Beate Elisabeth Maria Zunner Paul Zimmermann Maximilian Erlmann Barbara Obermayer-Pietsch Felix Aberer Othmar Moser |
| author_sort | Max Lennart Eckstein |
| collection | DOAJ |
| description | Background: It is unknown how different types of carbohydrates alter the cardio-autonomic system in healthy individuals. Therefore, the aim of this study was to investigate how heart-rate variability changes to single dose ingestion of glucose, fructose, glucose and fructose, and an artificial sweetener (sucralose). Methods: In a double-blind randomized crossover placebo-controlled setting, 15 participants received all study-specific substances in liquid form. During each 2-h visit, venous blood glucose was measured in a 5-min interval while heart-rate variability was measured continuously via Holter-electrocardiograph. Results: Ingestion of different types of carbohydrates and sucralose showed significant differences for heart rate (<i>p</i> < 0.001), SDNN (<i>p</i> < 0.008), RMSSD (<i>p</i> < 0.001), pNN50 (<i>p</i> < 0.001) and blood pressure (<i>p</i> < 0.001). Different glucose levels significantly altered parameters of heart-rate variability and blood pressure (all <i>p</i> < 0.001), while the rate of change in blood glucose led to changes in heart rate variability, but not in heart rate (<i>p</i> = 0.25) or blood pressure (<i>p</i> = 0.99). Conclusions: Ingestion of different types of carbohydrates lead to reductions in heart-rate variability compared to a placebo. Blood glucose values above or below 70–90 mg/dL decreased heart rate variability while this was also seen for rapid glucose changes, yet not as pronounced. Healthy individuals should be conscious about carbohydrate intake while maintaining blood glucose levels between 70–90 mg/dL. |
| first_indexed | 2024-03-09T22:33:38Z |
| format | Article |
| id | doaj.art-3405b19533594bebb8ba1c396d2b174c |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T22:33:38Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-3405b19533594bebb8ba1c396d2b174c2023-11-23T18:51:46ZengMDPI AGBiology2079-77372022-02-0111233810.3390/biology11020338Acute Changes in Heart Rate Variability to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled TrialMax Lennart Eckstein0Antonia Brockfeld1Sandra Haupt2Janis Ramon Schierbauer3Rebecca Tanja Zimmer4Nadine Bianca Wachsmuth5Beate Elisabeth Maria Zunner6Paul Zimmermann7Maximilian Erlmann8Barbara Obermayer-Pietsch9Felix Aberer10Othmar Moser11Division of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyEndocrinology Lab Platform, Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyDivision of Exercise Physiology and Metabolism, Department of Sport Science, University of Bayreuth, 95440 Bayreuth, GermanyBackground: It is unknown how different types of carbohydrates alter the cardio-autonomic system in healthy individuals. Therefore, the aim of this study was to investigate how heart-rate variability changes to single dose ingestion of glucose, fructose, glucose and fructose, and an artificial sweetener (sucralose). Methods: In a double-blind randomized crossover placebo-controlled setting, 15 participants received all study-specific substances in liquid form. During each 2-h visit, venous blood glucose was measured in a 5-min interval while heart-rate variability was measured continuously via Holter-electrocardiograph. Results: Ingestion of different types of carbohydrates and sucralose showed significant differences for heart rate (<i>p</i> < 0.001), SDNN (<i>p</i> < 0.008), RMSSD (<i>p</i> < 0.001), pNN50 (<i>p</i> < 0.001) and blood pressure (<i>p</i> < 0.001). Different glucose levels significantly altered parameters of heart-rate variability and blood pressure (all <i>p</i> < 0.001), while the rate of change in blood glucose led to changes in heart rate variability, but not in heart rate (<i>p</i> = 0.25) or blood pressure (<i>p</i> = 0.99). Conclusions: Ingestion of different types of carbohydrates lead to reductions in heart-rate variability compared to a placebo. Blood glucose values above or below 70–90 mg/dL decreased heart rate variability while this was also seen for rapid glucose changes, yet not as pronounced. Healthy individuals should be conscious about carbohydrate intake while maintaining blood glucose levels between 70–90 mg/dL.https://www.mdpi.com/2079-7737/11/2/338glucosefructosesucralosecardio-autonomic responseheart-rate variabilityhemodynamic changes |
| spellingShingle | Max Lennart Eckstein Antonia Brockfeld Sandra Haupt Janis Ramon Schierbauer Rebecca Tanja Zimmer Nadine Bianca Wachsmuth Beate Elisabeth Maria Zunner Paul Zimmermann Maximilian Erlmann Barbara Obermayer-Pietsch Felix Aberer Othmar Moser Acute Changes in Heart Rate Variability to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial Biology glucose fructose sucralose cardio-autonomic response heart-rate variability hemodynamic changes |
| title | Acute Changes in Heart Rate Variability to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_full | Acute Changes in Heart Rate Variability to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_fullStr | Acute Changes in Heart Rate Variability to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_full_unstemmed | Acute Changes in Heart Rate Variability to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_short | Acute Changes in Heart Rate Variability to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial |
| title_sort | acute changes in heart rate variability to glucose and fructose supplementation in healthy individuals a double blind randomized crossover placebo controlled trial |
| topic | glucose fructose sucralose cardio-autonomic response heart-rate variability hemodynamic changes |
| url | https://www.mdpi.com/2079-7737/11/2/338 |
| work_keys_str_mv | AT maxlennarteckstein acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT antoniabrockfeld acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT sandrahaupt acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT janisramonschierbauer acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT rebeccatanjazimmer acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT nadinebiancawachsmuth acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT beateelisabethmariazunner acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT paulzimmermann acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT maximilianerlmann acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT barbaraobermayerpietsch acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT felixaberer acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial AT othmarmoser acutechangesinheartratevariabilitytoglucoseandfructosesupplementationinhealthyindividualsadoubleblindrandomizedcrossoverplacebocontrolledtrial |