Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinoma
Background/Aims This study aimed to clarify the efficacy and safety of pancreatic duct lavage cytology combined with a cell-block method (PLC-CB) for possible pancreatic ductal adenocarcinomas (PDACs). Methods This study included 41 patients with suspected PDACs who underwent PLC-CB mainly because t...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2023-05-01
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| Series: | Clinical Endoscopy |
| Subjects: | |
| Online Access: | http://www.e-ce.org/upload/pdf/ce-2022-021.pdf |
| _version_ | 1797428924405252096 |
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| author | Hiroaki Kusunose Shinsuke Koshita Yoshihide Kanno Takahisa Ogawa Toshitaka Sakai Keisuke Yonamine Kazuaki Miyamoto Fumisato Kozakai Hideyuki Anan Kazuki Endo Haruka Okano Masaya Oikawa Takashi Tsuchiya Takashi Sawai Yutaka Noda Kei Ito |
| author_facet | Hiroaki Kusunose Shinsuke Koshita Yoshihide Kanno Takahisa Ogawa Toshitaka Sakai Keisuke Yonamine Kazuaki Miyamoto Fumisato Kozakai Hideyuki Anan Kazuki Endo Haruka Okano Masaya Oikawa Takashi Tsuchiya Takashi Sawai Yutaka Noda Kei Ito |
| author_sort | Hiroaki Kusunose |
| collection | DOAJ |
| description | Background/Aims This study aimed to clarify the efficacy and safety of pancreatic duct lavage cytology combined with a cell-block method (PLC-CB) for possible pancreatic ductal adenocarcinomas (PDACs). Methods This study included 41 patients with suspected PDACs who underwent PLC-CB mainly because they were unfit for undergoing endoscopic ultrasonography-guided fine needle aspiration. A 6-Fr double lumen catheter was mainly used to perform PLC-CB. Final diagnoses were obtained from the findings of resected specimens or clinical outcomes during surveillance after PLC-CB. Results Histocytological evaluations using PLC-CB were performed in 87.8% (36/41) of the patients. For 31 of the 36 patients, final diagnoses (invasive PDAC, 12; pancreatic carcinoma in situ, 5; benignancy, 14) were made, and the remaining five patients were excluded due to lack of surveillance periods after PLC-CB. For 31 patients, the sensitivity, specificity, and accuracy of PLC-CB for detecting malignancy were 94.1%, 100%, and 96.8%, respectively. In addition, they were 87.5%, 100%, and 94.1%, respectively, in 17 patients without pancreatic masses detectable using endoscopic ultrasonography. Four patients developed postprocedural pancreatitis, which improved with conservative therapy. Conclusions PLC-CB has an excellent ability to detect malignancies in patients with possible PDACs, including pancreatic carcinoma in situ. |
| first_indexed | 2024-03-09T09:05:52Z |
| format | Article |
| id | doaj.art-34061061543540149e9702d86fb9cd84 |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-09T09:05:52Z |
| publishDate | 2023-05-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-34061061543540149e9702d86fb9cd842023-12-02T10:22:52ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432023-05-0156335336610.5946/ce.2022.0217691Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinomaHiroaki Kusunose0Shinsuke Koshita1Yoshihide Kanno2Takahisa Ogawa3Toshitaka Sakai4Keisuke Yonamine5Kazuaki Miyamoto6Fumisato Kozakai7Hideyuki Anan8Kazuki Endo9Haruka Okano10Masaya Oikawa11Takashi Tsuchiya12Takashi Sawai13Yutaka Noda14Kei Ito15 Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Surgery, Sendai City Medical Center, Sendai, Japan Department of Surgery, Sendai City Medical Center, Sendai, Japan Department of Pathology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan Department of Gastroenterology, Sendai City Medical Center, Sendai, JapanBackground/Aims This study aimed to clarify the efficacy and safety of pancreatic duct lavage cytology combined with a cell-block method (PLC-CB) for possible pancreatic ductal adenocarcinomas (PDACs). Methods This study included 41 patients with suspected PDACs who underwent PLC-CB mainly because they were unfit for undergoing endoscopic ultrasonography-guided fine needle aspiration. A 6-Fr double lumen catheter was mainly used to perform PLC-CB. Final diagnoses were obtained from the findings of resected specimens or clinical outcomes during surveillance after PLC-CB. Results Histocytological evaluations using PLC-CB were performed in 87.8% (36/41) of the patients. For 31 of the 36 patients, final diagnoses (invasive PDAC, 12; pancreatic carcinoma in situ, 5; benignancy, 14) were made, and the remaining five patients were excluded due to lack of surveillance periods after PLC-CB. For 31 patients, the sensitivity, specificity, and accuracy of PLC-CB for detecting malignancy were 94.1%, 100%, and 96.8%, respectively. In addition, they were 87.5%, 100%, and 94.1%, respectively, in 17 patients without pancreatic masses detectable using endoscopic ultrasonography. Four patients developed postprocedural pancreatitis, which improved with conservative therapy. Conclusions PLC-CB has an excellent ability to detect malignancies in patients with possible PDACs, including pancreatic carcinoma in situ.http://www.e-ce.org/upload/pdf/ce-2022-021.pdfcarcinoma cell biologyendoscopic retrograde cholangiopancreatographypancreatic juicepancreatic neoplasms |
| spellingShingle | Hiroaki Kusunose Shinsuke Koshita Yoshihide Kanno Takahisa Ogawa Toshitaka Sakai Keisuke Yonamine Kazuaki Miyamoto Fumisato Kozakai Hideyuki Anan Kazuki Endo Haruka Okano Masaya Oikawa Takashi Tsuchiya Takashi Sawai Yutaka Noda Kei Ito Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinoma Clinical Endoscopy carcinoma cell biology endoscopic retrograde cholangiopancreatography pancreatic juice pancreatic neoplasms |
| title | Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinoma |
| title_full | Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinoma |
| title_fullStr | Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinoma |
| title_full_unstemmed | Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinoma |
| title_short | Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinoma |
| title_sort | pancreatic duct lavage cytology combined with a cell block method for patients with possible pancreatic ductal adenocarcinomas including pancreatic carcinoma |
| topic | carcinoma cell biology endoscopic retrograde cholangiopancreatography pancreatic juice pancreatic neoplasms |
| url | http://www.e-ce.org/upload/pdf/ce-2022-021.pdf |
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