DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus
Abstract Although genetic variations and environmental factors are vital to the development and progression of type 2 diabetes mellitus (T2DM), emerging literature suggest that epigenetics, especially DNA methylation, play a key role in the pathogenesis of T2DM by affecting insulin secretion of panc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12986-018-0283-x |
| _version_ | 1818966563539124224 |
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| author | Zheng Zhou Bao Sun Xiaoping Li Chunsheng Zhu |
| author_facet | Zheng Zhou Bao Sun Xiaoping Li Chunsheng Zhu |
| author_sort | Zheng Zhou |
| collection | DOAJ |
| description | Abstract Although genetic variations and environmental factors are vital to the development and progression of type 2 diabetes mellitus (T2DM), emerging literature suggest that epigenetics, especially DNA methylation, play a key role in the pathogenesis of T2DM by affecting insulin secretion of pancreatic β cells and the body’s resistance to insulin. Previous studies have elucidated how DNA methylation interacted with various factors in T2DM pathogenesis. This review summarized the role of related methylation genes in insulin-sensitive organs, such as pancreatic islets, skeletal muscle, liver, brain and adipose tissue, as well as peripheral blood cells, comparing the tissue similarity and specificity of methylated genes, aiming at a better understanding of the pathogenesis of T2DM and providing new ideas for the personalized treatment of this metabolism-associated disease. |
| first_indexed | 2024-12-20T13:34:54Z |
| format | Article |
| id | doaj.art-340719e33e9540df81abeaa82c2639fb |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-12-20T13:34:54Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-340719e33e9540df81abeaa82c2639fb2022-12-21T19:38:59ZengBMCNutrition & Metabolism1743-70752018-06-011511810.1186/s12986-018-0283-xDNA methylation landscapes in the pathogenesis of type 2 diabetes mellitusZheng Zhou0Bao Sun1Xiaoping Li2Chunsheng Zhu3Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Clinical Pharmacology, Xiangya Hospital, Central South UniversityDepartment of Chinese Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Chinese Medicine, The First Affiliated Hospital of Zhengzhou UniversityAbstract Although genetic variations and environmental factors are vital to the development and progression of type 2 diabetes mellitus (T2DM), emerging literature suggest that epigenetics, especially DNA methylation, play a key role in the pathogenesis of T2DM by affecting insulin secretion of pancreatic β cells and the body’s resistance to insulin. Previous studies have elucidated how DNA methylation interacted with various factors in T2DM pathogenesis. This review summarized the role of related methylation genes in insulin-sensitive organs, such as pancreatic islets, skeletal muscle, liver, brain and adipose tissue, as well as peripheral blood cells, comparing the tissue similarity and specificity of methylated genes, aiming at a better understanding of the pathogenesis of T2DM and providing new ideas for the personalized treatment of this metabolism-associated disease.http://link.springer.com/article/10.1186/s12986-018-0283-xT2DMDNA methylationInsulin secretionInsulin resistanceInsulin-sensitive organs |
| spellingShingle | Zheng Zhou Bao Sun Xiaoping Li Chunsheng Zhu DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus Nutrition & Metabolism T2DM DNA methylation Insulin secretion Insulin resistance Insulin-sensitive organs |
| title | DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus |
| title_full | DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus |
| title_fullStr | DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus |
| title_full_unstemmed | DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus |
| title_short | DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus |
| title_sort | dna methylation landscapes in the pathogenesis of type 2 diabetes mellitus |
| topic | T2DM DNA methylation Insulin secretion Insulin resistance Insulin-sensitive organs |
| url | http://link.springer.com/article/10.1186/s12986-018-0283-x |
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