Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We Consider Reducing the Dose for Females?
An important issue that is often neglected is the difference between male and female genders in response to medical treatments. In the context of COVID-19 vaccine administration, despite identical protocol strategies, it has been observed that females often suffer more adverse consequences than male...
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MDPI AG
2023-02-01
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Series: | Vaccines |
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Online Access: | https://www.mdpi.com/2076-393X/11/3/505 |
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author | Elena Azzolini Maximiliano Mollura Chiara Pozzi Leonardo Ubaldi Alberto Mantovani Carlo Selmi Riccardo Barbieri Maria Rescigno |
author_facet | Elena Azzolini Maximiliano Mollura Chiara Pozzi Leonardo Ubaldi Alberto Mantovani Carlo Selmi Riccardo Barbieri Maria Rescigno |
author_sort | Elena Azzolini |
collection | DOAJ |
description | An important issue that is often neglected is the difference between male and female genders in response to medical treatments. In the context of COVID-19 vaccine administration, despite identical protocol strategies, it has been observed that females often suffer more adverse consequences than males. Here, we analyzed the adverse events (AEs) of the Comirnaty vaccine in a population of 2385 healthcare workers as a function of age, sex, COVID-19 history and BMI. Using logistic regression analysis, we showed that these variables may contribute to the development of AEs, particularly in young subjects, females and individuals with a BMI below 25 kg/m<sup>2</sup>. Moreover, partial dependence plots indicate a 50% probability of developing a mild AE for a long period of time (≥7 days) or a severe AE of any duration in women below 40 years old and with a BMI < 20 kg/m<sup>2</sup>. As this effect is more evident after the second dose of the vaccine, we propose to reduce the amount of vaccine for any additional booster dose in relation to age, sex and BMI. This strategy might reduce adverse events without affecting vaccine efficacy. |
first_indexed | 2024-03-11T05:47:54Z |
format | Article |
id | doaj.art-34076f50caa3426dba5a0ed21c075ff0 |
institution | Directory Open Access Journal |
issn | 2076-393X |
language | English |
last_indexed | 2024-03-11T05:47:54Z |
publishDate | 2023-02-01 |
publisher | MDPI AG |
record_format | Article |
series | Vaccines |
spelling | doaj.art-34076f50caa3426dba5a0ed21c075ff02023-11-17T14:17:00ZengMDPI AGVaccines2076-393X2023-02-0111350510.3390/vaccines11030505Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We Consider Reducing the Dose for Females?Elena Azzolini0Maximiliano Mollura1Chiara Pozzi2Leonardo Ubaldi3Alberto Mantovani4Carlo Selmi5Riccardo Barbieri6Maria Rescigno7IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, ItalyPolitecnico di Milano, Department of Electronic, Information and Bioengineering, Piazza Leonardo da Vinci 32, 20133 Milano, MI, ItalyIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, MI, ItalyIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, ItalyIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, ItalyPolitecnico di Milano, Department of Electronic, Information and Bioengineering, Piazza Leonardo da Vinci 32, 20133 Milano, MI, ItalyIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, MI, ItalyAn important issue that is often neglected is the difference between male and female genders in response to medical treatments. In the context of COVID-19 vaccine administration, despite identical protocol strategies, it has been observed that females often suffer more adverse consequences than males. Here, we analyzed the adverse events (AEs) of the Comirnaty vaccine in a population of 2385 healthcare workers as a function of age, sex, COVID-19 history and BMI. Using logistic regression analysis, we showed that these variables may contribute to the development of AEs, particularly in young subjects, females and individuals with a BMI below 25 kg/m<sup>2</sup>. Moreover, partial dependence plots indicate a 50% probability of developing a mild AE for a long period of time (≥7 days) or a severe AE of any duration in women below 40 years old and with a BMI < 20 kg/m<sup>2</sup>. As this effect is more evident after the second dose of the vaccine, we propose to reduce the amount of vaccine for any additional booster dose in relation to age, sex and BMI. This strategy might reduce adverse events without affecting vaccine efficacy.https://www.mdpi.com/2076-393X/11/3/505vaccineCOVID-19adverse events |
spellingShingle | Elena Azzolini Maximiliano Mollura Chiara Pozzi Leonardo Ubaldi Alberto Mantovani Carlo Selmi Riccardo Barbieri Maria Rescigno Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We Consider Reducing the Dose for Females? Vaccines vaccine COVID-19 adverse events |
title | Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We Consider Reducing the Dose for Females? |
title_full | Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We Consider Reducing the Dose for Females? |
title_fullStr | Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We Consider Reducing the Dose for Females? |
title_full_unstemmed | Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We Consider Reducing the Dose for Females? |
title_short | Adverse Events to Comirnaty Vaccine Are Linked to Sex, Age and BMI: Should We Consider Reducing the Dose for Females? |
title_sort | adverse events to comirnaty vaccine are linked to sex age and bmi should we consider reducing the dose for females |
topic | vaccine COVID-19 adverse events |
url | https://www.mdpi.com/2076-393X/11/3/505 |
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