Distinct subtypes of endometriosis identified based on stromal-immune microenvironment and gene expression: implications for hormone therapy

Distinct subtypes of endometriosis identified based on stromal-immune microenvironment and gene expression: implications for hormone therapy

BackgroundEndometriosis (EMs) is a chronic inflammatory condition that is highly heterogeneous. Current clinical staging fails to accurately predict drug responses and prognosis. In this study, we aimed to reveal the heterogeneity of ectopic lesions and investigate the possible underlying mechanisms...

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Bibliographic Details
Main Authors: Yuning Wang, Yun Chen, Yinping Xiao, Jingyao Ruan, Qi Tian, Qi Cheng, Kaikai Chang, Xiaofang Yi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
endometriosis
heterogeneity
subtype
immune infiltration
fibroblast activation
unsupervised hierarchical clustering
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1133672/full

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