An unusual case of an osteosarcoma arising in a leiomyoma of the uterus
Leiomyoma is the most common uterine neoplasm. It has several histological variants such as atypical, cellular, myxoid, and epithelioid. Leiomyoma with heterologous elements is a rare variant of leiomyoma, which may contain heterologous elements such as fat, skeletal muscle, and chondroid and osseou...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2012-09-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2012.23.5.1111 |
| _version_ | 1818451251591905280 |
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| author | Mehmet Kefeli Sancar Baris Oguz Aydin Levent Yıldız Seda Yamak Bedri Kandemir |
| author_facet | Mehmet Kefeli Sancar Baris Oguz Aydin Levent Yıldız Seda Yamak Bedri Kandemir |
| author_sort | Mehmet Kefeli |
| collection | DOAJ |
| description | Leiomyoma is the most common uterine neoplasm. It has several histological variants such as atypical, cellular, myxoid, and epithelioid. Leiomyoma with heterologous elements is a rare variant of leiomyoma, which may contain heterologous elements such as fat, skeletal muscle, and chondroid and osseous tissues. The heterologous sarcomatous differentiation is also rarely seen. We report on a 53-year-old woman who was admitted with abnormal vaginal bleeding and symptoms related to an abdominal mass. She had a huge uterine leiomyoma that contained osteosarcomatous differentiation in several foci. Although malignant progression for leiomyoma is exceedingly rare, when it occurs it may result not only in a leiomyosarcoma but also in a heterologous sarcomatous differention. We have reported histopathological, immunohistochemical, and clinical features of this rare case and reviewed the published studies. |
| first_indexed | 2024-12-14T21:04:14Z |
| format | Article |
| id | doaj.art-340a7854a1f8417399c90ab06d564976 |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-12-14T21:04:14Z |
| publishDate | 2012-09-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-340a7854a1f8417399c90ab06d5649762022-12-21T22:47:30ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662012-09-0132554454610.5144/0256-4947.2012.23.5.1111asm-5-544An unusual case of an osteosarcoma arising in a leiomyoma of the uterusMehmet Kefeli0Sancar Baris1Oguz Aydin2Levent Yıldız3Seda Yamak4Bedri Kandemir5From the Department of Pathology, Ondokuz Mayis University, Medical School, Gazi State Hospital, Samsun, TurkeyFrom the Department of Pathology, Ondokuz Mayis University, Medical School, Gazi State Hospital, Samsun, TurkeyFrom the Department of Pathology, Ondokuz Mayis University, Medical School, Gazi State Hospital, Samsun, TurkeyFrom the Department of Pathology, Ondokuz Mayis University, Medical School, Gazi State Hospital, Samsun, TurkeyFrom the Department of Pathology, Ondokuz Mayis University, Medical School, Gazi State Hospital, Samsun, TurkeyFrom the Department of Pathology, Ondokuz Mayis University, Medical School, Gazi State Hospital, Samsun, TurkeyLeiomyoma is the most common uterine neoplasm. It has several histological variants such as atypical, cellular, myxoid, and epithelioid. Leiomyoma with heterologous elements is a rare variant of leiomyoma, which may contain heterologous elements such as fat, skeletal muscle, and chondroid and osseous tissues. The heterologous sarcomatous differentiation is also rarely seen. We report on a 53-year-old woman who was admitted with abnormal vaginal bleeding and symptoms related to an abdominal mass. She had a huge uterine leiomyoma that contained osteosarcomatous differentiation in several foci. Although malignant progression for leiomyoma is exceedingly rare, when it occurs it may result not only in a leiomyosarcoma but also in a heterologous sarcomatous differention. We have reported histopathological, immunohistochemical, and clinical features of this rare case and reviewed the published studies.https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2012.23.5.1111 |
| spellingShingle | Mehmet Kefeli Sancar Baris Oguz Aydin Levent Yıldız Seda Yamak Bedri Kandemir An unusual case of an osteosarcoma arising in a leiomyoma of the uterus Annals of Saudi Medicine |
| title | An unusual case of an osteosarcoma arising in a leiomyoma of the uterus |
| title_full | An unusual case of an osteosarcoma arising in a leiomyoma of the uterus |
| title_fullStr | An unusual case of an osteosarcoma arising in a leiomyoma of the uterus |
| title_full_unstemmed | An unusual case of an osteosarcoma arising in a leiomyoma of the uterus |
| title_short | An unusual case of an osteosarcoma arising in a leiomyoma of the uterus |
| title_sort | unusual case of an osteosarcoma arising in a leiomyoma of the uterus |
| url | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2012.23.5.1111 |
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