Genomic Determinants of Knee Joint Biomechanics: An Exploration into the Molecular Basis of Locomotor Function, a Narrative Review
In recent years, the nexus between genetics and biomechanics has garnered significant attention, elucidating the role of genomic determinants in shaping the biomechanical attributes of human joints, specifically the knee. This review seeks to provide a comprehensive exploration of the molecular basi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/46/2/79 |
| _version_ | 1797298539808686080 |
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| author | Georgian-Longin Iacobescu Loredana Iacobescu Mihnea Ioan Gabriel Popa Razvan-Adrian Covache-Busuioc Antonio-Daniel Corlatescu Catalin Cirstoiu |
| author_facet | Georgian-Longin Iacobescu Loredana Iacobescu Mihnea Ioan Gabriel Popa Razvan-Adrian Covache-Busuioc Antonio-Daniel Corlatescu Catalin Cirstoiu |
| author_sort | Georgian-Longin Iacobescu |
| collection | DOAJ |
| description | In recent years, the nexus between genetics and biomechanics has garnered significant attention, elucidating the role of genomic determinants in shaping the biomechanical attributes of human joints, specifically the knee. This review seeks to provide a comprehensive exploration of the molecular basis underlying knee joint locomotor function. Leveraging advancements in genomic sequencing, we identified specific genetic markers and polymorphisms tied to key biomechanical features of the knee, such as ligament elasticity, meniscal resilience, and cartilage health. Particular attention was devoted to collagen genes like COL1A1 and COL5A1 and their influence on ligamentous strength and injury susceptibility. We further investigated the genetic underpinnings of knee osteoarthritis onset and progression, as well as the potential for personalized rehabilitation strategies tailored to an individual’s genetic profile. We reviewed the impact of genetic factors on knee biomechanics and highlighted the importance of personalized orthopedic interventions. The results hold significant implications for injury prevention, treatment optimization, and the future of regenerative medicine, targeting not only knee joint health but joint health in general. |
| first_indexed | 2024-03-07T22:37:28Z |
| format | Article |
| id | doaj.art-340a7ffea2754376b3f69fb7ce5a1f4b |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-07T22:37:28Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-340a7ffea2754376b3f69fb7ce5a1f4b2024-02-23T15:12:36ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-02-014621237125810.3390/cimb46020079Genomic Determinants of Knee Joint Biomechanics: An Exploration into the Molecular Basis of Locomotor Function, a Narrative ReviewGeorgian-Longin Iacobescu0Loredana Iacobescu1Mihnea Ioan Gabriel Popa2Razvan-Adrian Covache-Busuioc3Antonio-Daniel Corlatescu4Catalin Cirstoiu5Orthopaedics and Traumatology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaOrthopaedics and Traumatology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaOrthopaedics and Traumatology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaOrthopaedics and Traumatology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaOrthopaedics and Traumatology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaOrthopaedics and Traumatology Department, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaIn recent years, the nexus between genetics and biomechanics has garnered significant attention, elucidating the role of genomic determinants in shaping the biomechanical attributes of human joints, specifically the knee. This review seeks to provide a comprehensive exploration of the molecular basis underlying knee joint locomotor function. Leveraging advancements in genomic sequencing, we identified specific genetic markers and polymorphisms tied to key biomechanical features of the knee, such as ligament elasticity, meniscal resilience, and cartilage health. Particular attention was devoted to collagen genes like COL1A1 and COL5A1 and their influence on ligamentous strength and injury susceptibility. We further investigated the genetic underpinnings of knee osteoarthritis onset and progression, as well as the potential for personalized rehabilitation strategies tailored to an individual’s genetic profile. We reviewed the impact of genetic factors on knee biomechanics and highlighted the importance of personalized orthopedic interventions. The results hold significant implications for injury prevention, treatment optimization, and the future of regenerative medicine, targeting not only knee joint health but joint health in general.https://www.mdpi.com/1467-3045/46/2/79knee biomechanicsosteoarthritisCOL1A1COL5A1extracellular matrixproteoglycans |
| spellingShingle | Georgian-Longin Iacobescu Loredana Iacobescu Mihnea Ioan Gabriel Popa Razvan-Adrian Covache-Busuioc Antonio-Daniel Corlatescu Catalin Cirstoiu Genomic Determinants of Knee Joint Biomechanics: An Exploration into the Molecular Basis of Locomotor Function, a Narrative Review Current Issues in Molecular Biology knee biomechanics osteoarthritis COL1A1 COL5A1 extracellular matrix proteoglycans |
| title | Genomic Determinants of Knee Joint Biomechanics: An Exploration into the Molecular Basis of Locomotor Function, a Narrative Review |
| title_full | Genomic Determinants of Knee Joint Biomechanics: An Exploration into the Molecular Basis of Locomotor Function, a Narrative Review |
| title_fullStr | Genomic Determinants of Knee Joint Biomechanics: An Exploration into the Molecular Basis of Locomotor Function, a Narrative Review |
| title_full_unstemmed | Genomic Determinants of Knee Joint Biomechanics: An Exploration into the Molecular Basis of Locomotor Function, a Narrative Review |
| title_short | Genomic Determinants of Knee Joint Biomechanics: An Exploration into the Molecular Basis of Locomotor Function, a Narrative Review |
| title_sort | genomic determinants of knee joint biomechanics an exploration into the molecular basis of locomotor function a narrative review |
| topic | knee biomechanics osteoarthritis COL1A1 COL5A1 extracellular matrix proteoglycans |
| url | https://www.mdpi.com/1467-3045/46/2/79 |
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