Hydrogen Bond Assisted Three-Component Tandem Reactions to Access <i>N</i>-Alkyl-4-Quinolones
Hydrogen-bonding catalytic reactions have gained great interest. Herein, a hydrogen-bond-assisted three-component tandem reaction for the efficient synthesis of <i>N</i>-alkyl-4-quinolones is described. This novel strategy features the first proof of polyphosphate ester (PPE) as a dual h...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/5/2304 |
| Summary: | Hydrogen-bonding catalytic reactions have gained great interest. Herein, a hydrogen-bond-assisted three-component tandem reaction for the efficient synthesis of <i>N</i>-alkyl-4-quinolones is described. This novel strategy features the first proof of polyphosphate ester (PPE) as a dual hydrogen-bonding catalyst and the use of readily available starting materials for the preparation of <i>N</i>-alkyl-4-quinolones. The method provides a diversity of <i>N</i>-alkyl-4-quinolones in moderate to good yields. The compound <b>4h</b> demonstrated good neuroprotective activity against <i>N</i>-methyl-ᴅ-aspartate (NMDA)-induced excitotoxicity in PC12 cells. |
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| ISSN: | 1420-3049 |