Effects of smoking cessation on central blood pressure and arterial stiffness
Takeshi Takami1,Yoshihiko Saito21Department of Internal Medicine, Clinic Jingumae, Kashihara, Nara, Japan; 2First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, JapanPurpose: Smoking affects arterial stiffness, thus causing an elevation in central blood pressure (CBP). Th...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2011-10-01
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| Series: | Vascular Health and Risk Management |
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| Online Access: | https://www.dovepress.com/effects-of-smoking-cessation-on-central-blood-pressure-and-arterial-st-peer-reviewed-article-VHRM |
| _version_ | 1818193975036608512 |
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| author | Takami T Saito |
| author_facet | Takami T Saito |
| author_sort | Takami T |
| collection | DOAJ |
| description | Takeshi Takami1,Yoshihiko Saito21Department of Internal Medicine, Clinic Jingumae, Kashihara, Nara, Japan; 2First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, JapanPurpose: Smoking affects arterial stiffness, thus causing an elevation in central blood pressure (CBP). The present study was designed to examine whether smoking cessation treatment improved CBP and arterial stiffness.Patients and methods: We conducted an observational study of 70 patients receiving smoking cessation treatment. Before and 60 weeks after the start of a 12-week varenicline treatment, we measured brachial blood pressure, CBP, brachial-ankle pulse wave velocity (baPWV), normalized radial augmentation index (rAIx@75), left ventricular weight, and left ventricular diastolic function of each patient. The data were compared between the patients who succeeded in quitting smoking (smoking cessation group; n = 37) and those who failed to quit smoking (smoking group; n = 33).Results: Baseline characteristics were similar in both groups. Brachial blood pressure remained unchanged in both groups. CBP, baPWV, and rAIx@75 decreased significantly in the smoking cessation group, while these parameters showed no significant change in the smoking group. Thus, CBP, baPWV, and rAIx@75 showed greater decrease in the smoking cessation group than in the smoking group (CBP, −7.1 ± 1.4 mmHg vs 1.2 ± 2.7 mmHg; P < 0.01; baPWV, −204 ± 64 cm/s vs −43 ± 72 cm/s; P < 0.01; rAIx@75, −6.4 ± 2.8% vs −1.0 ± 3.9%; P < 0.01). Left ventricular weight and left ventricular diastolic function remained unchanged in both groups.Conclusion: Patients in the smoking cessation group showed significant improvement in CBP, baPWV, and rAIx@75. These results indicate that smoking cessation can improve arterial stiffness and CBP.Keywords: central blood pressure, augmentation index, brachial-ankle pulse wave velocity, smoking cessation, varenicline |
| first_indexed | 2024-12-12T00:54:56Z |
| format | Article |
| id | doaj.art-340d609a6d3f4defaaaefea568ab7b98 |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-12T00:54:56Z |
| publishDate | 2011-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-340d609a6d3f4defaaaefea568ab7b982022-12-22T00:43:53ZengDove Medical PressVascular Health and Risk Management1178-20482011-10-01Volume 76336388517Effects of smoking cessation on central blood pressure and arterial stiffnessTakami TSaitoTakeshi Takami1,Yoshihiko Saito21Department of Internal Medicine, Clinic Jingumae, Kashihara, Nara, Japan; 2First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, JapanPurpose: Smoking affects arterial stiffness, thus causing an elevation in central blood pressure (CBP). The present study was designed to examine whether smoking cessation treatment improved CBP and arterial stiffness.Patients and methods: We conducted an observational study of 70 patients receiving smoking cessation treatment. Before and 60 weeks after the start of a 12-week varenicline treatment, we measured brachial blood pressure, CBP, brachial-ankle pulse wave velocity (baPWV), normalized radial augmentation index (rAIx@75), left ventricular weight, and left ventricular diastolic function of each patient. The data were compared between the patients who succeeded in quitting smoking (smoking cessation group; n = 37) and those who failed to quit smoking (smoking group; n = 33).Results: Baseline characteristics were similar in both groups. Brachial blood pressure remained unchanged in both groups. CBP, baPWV, and rAIx@75 decreased significantly in the smoking cessation group, while these parameters showed no significant change in the smoking group. Thus, CBP, baPWV, and rAIx@75 showed greater decrease in the smoking cessation group than in the smoking group (CBP, −7.1 ± 1.4 mmHg vs 1.2 ± 2.7 mmHg; P < 0.01; baPWV, −204 ± 64 cm/s vs −43 ± 72 cm/s; P < 0.01; rAIx@75, −6.4 ± 2.8% vs −1.0 ± 3.9%; P < 0.01). Left ventricular weight and left ventricular diastolic function remained unchanged in both groups.Conclusion: Patients in the smoking cessation group showed significant improvement in CBP, baPWV, and rAIx@75. These results indicate that smoking cessation can improve arterial stiffness and CBP.Keywords: central blood pressure, augmentation index, brachial-ankle pulse wave velocity, smoking cessation, vareniclinehttps://www.dovepress.com/effects-of-smoking-cessation-on-central-blood-pressure-and-arterial-st-peer-reviewed-article-VHRMcentral blood pressureaugmentation indexbrachial-ankle pulse wave velocitysmoking cessationvarenicline |
| spellingShingle | Takami T Saito Effects of smoking cessation on central blood pressure and arterial stiffness Vascular Health and Risk Management central blood pressure augmentation index brachial-ankle pulse wave velocity smoking cessation varenicline |
| title | Effects of smoking cessation on central blood pressure and arterial stiffness |
| title_full | Effects of smoking cessation on central blood pressure and arterial stiffness |
| title_fullStr | Effects of smoking cessation on central blood pressure and arterial stiffness |
| title_full_unstemmed | Effects of smoking cessation on central blood pressure and arterial stiffness |
| title_short | Effects of smoking cessation on central blood pressure and arterial stiffness |
| title_sort | effects of smoking cessation on central blood pressure and arterial stiffness |
| topic | central blood pressure augmentation index brachial-ankle pulse wave velocity smoking cessation varenicline |
| url | https://www.dovepress.com/effects-of-smoking-cessation-on-central-blood-pressure-and-arterial-st-peer-reviewed-article-VHRM |
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