Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury

Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury

Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine (8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic effects. Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), reads oxidative substrates and participates in trans...

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Bibliographic Details
Main Authors: Lang Pan, Spiros Vlahopoulos, Lloyd Tanner, Jesper Bergwik, Attila Bacsi, Zsolt Radak, Arne Egesten, Xueqing Ba, Allan R. Brasier, Istvan Boldogh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
ROS
epigenetics
NFκB
SMADs
inflammation
remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186369/full

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