High-throughput screening and quantitative analysis of hidden ingredients in plant protection products by GC-MS/MS
Hidden ingredients in plant protection products (PPPs) threaten public health, food trade, and the environment. In this study, we developed a high-throughput screening method of 639 hidden ingredients in PPPs using GC-MS/MS in multiple reaction monitoring mode. Results showed that the qualitative cr...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323010606 |
| _version_ | 1797643588697325568 |
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| author | Xiaohui Li Chunmei Li Simeng Li Xueying Chen Ning Yue Qi Wang Chen Zhang Hua Shao Lufei Zheng Fen Jin |
| author_facet | Xiaohui Li Chunmei Li Simeng Li Xueying Chen Ning Yue Qi Wang Chen Zhang Hua Shao Lufei Zheng Fen Jin |
| author_sort | Xiaohui Li |
| collection | DOAJ |
| description | Hidden ingredients in plant protection products (PPPs) threaten public health, food trade, and the environment. In this study, we developed a high-throughput screening method of 639 hidden ingredients in PPPs using GC-MS/MS in multiple reaction monitoring mode. Results showed that the qualitative criteria of retention time (tR) shift and uncertainty of qualifier to quantifier ratio in the commercially available Shimadzu Smart Pesticides Database were set at < 0.17 min and < 30%, respectively, which could be used to tentatively identify compounds without standards. The limits of quantification were 0.01–0.05 mg/kg. A wide linear range of 10–1000 μg/L was observed with R2 ≥ 0.975. Recoveries from three types of PPP formulations were 62.08%− 126.3%, with relative standard deviations < 15.7%. Finally, this method was applied to screen and quantify hidden ingredients in 91 plant protection products (PPPs) samples collected from online sales in China. Only one hidden ingredient, dimethomorph (1.6 g/kg), was detected in the polyoxin formulation (15% wettable powder). The results will be helpful in assessing the potential risks of hidden ingredients in PPPs. |
| first_indexed | 2024-03-11T14:17:04Z |
| format | Article |
| id | doaj.art-340f28906efe49ad89ecac1311b936af |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-11T14:17:04Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-340f28906efe49ad89ecac1311b936af2023-11-01T04:45:53ZengElsevierEcotoxicology and Environmental Safety0147-65132023-11-01266115556High-throughput screening and quantitative analysis of hidden ingredients in plant protection products by GC-MS/MSXiaohui Li0Chunmei Li1Simeng Li2Xueying Chen3Ning Yue4Qi Wang5Chen Zhang6Hua Shao7Lufei Zheng8Fen Jin9Key Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, ChinaInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, ChinaKey Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, ChinaKey Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, ChinaKey Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, ChinaKey Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, ChinaKey Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, ChinaKey Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, ChinaKey Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, ChinaKey Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, China; Corresponding author.Hidden ingredients in plant protection products (PPPs) threaten public health, food trade, and the environment. In this study, we developed a high-throughput screening method of 639 hidden ingredients in PPPs using GC-MS/MS in multiple reaction monitoring mode. Results showed that the qualitative criteria of retention time (tR) shift and uncertainty of qualifier to quantifier ratio in the commercially available Shimadzu Smart Pesticides Database were set at < 0.17 min and < 30%, respectively, which could be used to tentatively identify compounds without standards. The limits of quantification were 0.01–0.05 mg/kg. A wide linear range of 10–1000 μg/L was observed with R2 ≥ 0.975. Recoveries from three types of PPP formulations were 62.08%− 126.3%, with relative standard deviations < 15.7%. Finally, this method was applied to screen and quantify hidden ingredients in 91 plant protection products (PPPs) samples collected from online sales in China. Only one hidden ingredient, dimethomorph (1.6 g/kg), was detected in the polyoxin formulation (15% wettable powder). The results will be helpful in assessing the potential risks of hidden ingredients in PPPs.http://www.sciencedirect.com/science/article/pii/S0147651323010606High-throughput screeningPlant protection productsHidden ingredientsGC-MS/MS |
| spellingShingle | Xiaohui Li Chunmei Li Simeng Li Xueying Chen Ning Yue Qi Wang Chen Zhang Hua Shao Lufei Zheng Fen Jin High-throughput screening and quantitative analysis of hidden ingredients in plant protection products by GC-MS/MS Ecotoxicology and Environmental Safety High-throughput screening Plant protection products Hidden ingredients GC-MS/MS |
| title | High-throughput screening and quantitative analysis of hidden ingredients in plant protection products by GC-MS/MS |
| title_full | High-throughput screening and quantitative analysis of hidden ingredients in plant protection products by GC-MS/MS |
| title_fullStr | High-throughput screening and quantitative analysis of hidden ingredients in plant protection products by GC-MS/MS |
| title_full_unstemmed | High-throughput screening and quantitative analysis of hidden ingredients in plant protection products by GC-MS/MS |
| title_short | High-throughput screening and quantitative analysis of hidden ingredients in plant protection products by GC-MS/MS |
| title_sort | high throughput screening and quantitative analysis of hidden ingredients in plant protection products by gc ms ms |
| topic | High-throughput screening Plant protection products Hidden ingredients GC-MS/MS |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323010606 |
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