Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols
A new series of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ol derivatives was synthesized by Michael addition of chalcones 5a–j with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structural assignment of the produc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2019-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391800113A.pdf |
| _version_ | 1818142607323168768 |
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| author | Ashok Dongamanti Kavitha Rangu Gundu Srinivas Sarasija Madderla |
| author_facet | Ashok Dongamanti Kavitha Rangu Gundu Srinivas Sarasija Madderla |
| author_sort | Ashok Dongamanti |
| collection | DOAJ |
| description | A new series of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ol derivatives was synthesized by Michael addition of chalcones 5a–j with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structural assignment of the products was confirmed based on IR, 1H-NMR, 13C-NMR, MS and analytical data. All the synthesized compounds 6a–j were screened for their antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and compounds 6c–f and 6i showed promising antimicrobial potency. |
| first_indexed | 2024-12-11T11:18:28Z |
| format | Article |
| id | doaj.art-341040acc0564f0480ec19c611c1a20b |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-11T11:18:28Z |
| publishDate | 2019-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-341040acc0564f0480ec19c611c1a20b2022-12-22T01:09:14ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212019-01-0184323724410.2298/JSC171206113A0352-51391800113AMicrowave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-olsAshok Dongamanti0Kavitha Rangu1Gundu Srinivas2Sarasija Madderla3Osmania University, Department of Chemistry, Green and Medicinal Chemistry Laboratory, Hyderabad, IndiaOsmania University, Department of Chemistry, Green and Medicinal Chemistry Laboratory, Hyderabad, IndiaOsmania University, Department of Chemistry, Green and Medicinal Chemistry Laboratory, Hyderabad, IndiaDepartment of Chemistry, Satavahana University, Karimnagar, IndiaA new series of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ol derivatives was synthesized by Michael addition of chalcones 5a–j with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structural assignment of the products was confirmed based on IR, 1H-NMR, 13C-NMR, MS and analytical data. All the synthesized compounds 6a–j were screened for their antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and compounds 6c–f and 6i showed promising antimicrobial potency.http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391800113A.pdfpyrazolepyrazolinemicrowave irradiationantimicrobial activity |
| spellingShingle | Ashok Dongamanti Kavitha Rangu Gundu Srinivas Sarasija Madderla Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols Journal of the Serbian Chemical Society pyrazole pyrazoline microwave irradiation antimicrobial activity |
| title | Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols |
| title_full | Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols |
| title_fullStr | Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols |
| title_full_unstemmed | Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols |
| title_short | Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols |
| title_sort | microwave assisted synthesis and antimicrobial evaluation of 6 3 aryl 1 phenyl 4 5 dihydro 4 5 bi 1h pyrazol 3 yl 2h chromen 5 ols |
| topic | pyrazole pyrazoline microwave irradiation antimicrobial activity |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391800113A.pdf |
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