Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats
Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo. KO characterization showed that 74.96% of the un...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1003627/full |
| _version_ | 1818022990372143104 |
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| author | Luqiang Huang Luqiang Huang Luqiang Huang Wenxin Wu Linshan Huang Jiaze Zhong Lei Chen Meiying Wang Huibin Chen Huibin Chen |
| author_facet | Luqiang Huang Luqiang Huang Luqiang Huang Wenxin Wu Linshan Huang Jiaze Zhong Lei Chen Meiying Wang Huibin Chen Huibin Chen |
| author_sort | Luqiang Huang |
| collection | DOAJ |
| description | Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo. KO characterization showed that 74.96% of the unsaturated fatty acids consist of oleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Rats pre-treated with KO (100, 200, and 500 mg/kg) showed mitigated oxidative stress through enhanced antioxidant enzyme superoxide dismutase (SOD) and reducing enzymes malondialdehyde (MDA) and myeloperoxidase (MPO) in gastric mucosal injury induced by ethanol. Additionally, the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), the expression of the IκBα/NF-κB signaling pathway, and nitric oxide (NO) production was suppressed. The results also demonstrated a significant decrease in histological injury and hemorrhage scores in a dose-dependent manner in the KO range. Therefore, KO has potential as a food supplement to alleviate ethanol-induced acute gastric mucosal injury. |
| first_indexed | 2024-12-10T03:37:12Z |
| format | Article |
| id | doaj.art-3410c24ac56e4644abbc9f3ecb4459a7 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-10T03:37:12Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-3410c24ac56e4644abbc9f3ecb4459a72022-12-22T02:03:41ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.10036271003627Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in ratsLuqiang Huang0Luqiang Huang1Luqiang Huang2Wenxin Wu3Linshan Huang4Jiaze Zhong5Lei Chen6Meiying Wang7Huibin Chen8Huibin Chen9College of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, ChinaThe Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Product of State Oceanic Administration, Fujian Normal University, Fuzhou, ChinaMarine Active Substance and Product Technology Research and Development Center of Ocean Research Institute of Fuzhou, Fujian Normal University, Fuzhou, ChinaCollege of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, ChinaCollege of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, ChinaCollege of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Zhanjiang, ChinaSchool of Engineering, University of Guelph, Guelph, ON, CanadaCollege of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, ChinaThe Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Product of State Oceanic Administration, Fujian Normal University, Fuzhou, ChinaAntarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo. KO characterization showed that 74.96% of the unsaturated fatty acids consist of oleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Rats pre-treated with KO (100, 200, and 500 mg/kg) showed mitigated oxidative stress through enhanced antioxidant enzyme superoxide dismutase (SOD) and reducing enzymes malondialdehyde (MDA) and myeloperoxidase (MPO) in gastric mucosal injury induced by ethanol. Additionally, the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), the expression of the IκBα/NF-κB signaling pathway, and nitric oxide (NO) production was suppressed. The results also demonstrated a significant decrease in histological injury and hemorrhage scores in a dose-dependent manner in the KO range. Therefore, KO has potential as a food supplement to alleviate ethanol-induced acute gastric mucosal injury.https://www.frontiersin.org/articles/10.3389/fnut.2022.1003627/fullAntarctic krill oilsupercritical carbon dioxide extractiongastric mucosal injuryinflammationpolyunsaturated fatty acid |
| spellingShingle | Luqiang Huang Luqiang Huang Luqiang Huang Wenxin Wu Linshan Huang Jiaze Zhong Lei Chen Meiying Wang Huibin Chen Huibin Chen Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats Frontiers in Nutrition Antarctic krill oil supercritical carbon dioxide extraction gastric mucosal injury inflammation polyunsaturated fatty acid |
| title | Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
| title_full | Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
| title_fullStr | Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
| title_full_unstemmed | Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
| title_short | Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats |
| title_sort | antarctic krill euphausia superba oil modulatory effects on ethanol induced acute injury of the gastric mucosa in rats |
| topic | Antarctic krill oil supercritical carbon dioxide extraction gastric mucosal injury inflammation polyunsaturated fatty acid |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1003627/full |
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