IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells.
Proteins of the IQGAP family display complicated and often contradictory activities in tumorigenesis. IQGAP1 has well documented oncogenic potential and IQGAP2 has putative tumor-suppressive function. IQGAP3 is the latest addition to this family and its role in cancer development remains to be defin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4029748?pdf=render |
| _version_ | 1811320810986536960 |
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| author | Ying Yang Wei Zhao Qing-Wen Xu Xiao-Song Wang Yu Zhang Jun Zhang |
| author_facet | Ying Yang Wei Zhao Qing-Wen Xu Xiao-Song Wang Yu Zhang Jun Zhang |
| author_sort | Ying Yang |
| collection | DOAJ |
| description | Proteins of the IQGAP family display complicated and often contradictory activities in tumorigenesis. IQGAP1 has well documented oncogenic potential and IQGAP2 has putative tumor-suppressive function. IQGAP3 is the latest addition to this family and its role in cancer development remains to be defined. Here we demonstrate IQGAP3 expression is markedly increased in lung cancer tissues at both mRNA and protein levels. Overexpression of IQGAP3 promoted tumor cell growth, and migration and invasion, whereas knockdown of IQGAP3 exhibited opposite effects. Moreover, suppression of IQGAP3 in a lung cancer cell line caused a reduction in the tumorigenicity of these cells in lung tissue after intravenous injection. Furthermore, we showed that IQGAP3 is able to interact with ERK1 and enhance its phosphorylation following treatment with EGF. These data suggest that IQGAP3 may contribute to the pathogenesis of lung cancer by modulating EGFR-ERK signaling. |
| first_indexed | 2024-04-13T13:07:12Z |
| format | Article |
| id | doaj.art-3411a128f3f84aba8be3667e6e8b98a0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T13:07:12Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3411a128f3f84aba8be3667e6e8b98a02022-12-22T02:45:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9757810.1371/journal.pone.0097578IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells.Ying YangWei ZhaoQing-Wen XuXiao-Song WangYu ZhangJun ZhangProteins of the IQGAP family display complicated and often contradictory activities in tumorigenesis. IQGAP1 has well documented oncogenic potential and IQGAP2 has putative tumor-suppressive function. IQGAP3 is the latest addition to this family and its role in cancer development remains to be defined. Here we demonstrate IQGAP3 expression is markedly increased in lung cancer tissues at both mRNA and protein levels. Overexpression of IQGAP3 promoted tumor cell growth, and migration and invasion, whereas knockdown of IQGAP3 exhibited opposite effects. Moreover, suppression of IQGAP3 in a lung cancer cell line caused a reduction in the tumorigenicity of these cells in lung tissue after intravenous injection. Furthermore, we showed that IQGAP3 is able to interact with ERK1 and enhance its phosphorylation following treatment with EGF. These data suggest that IQGAP3 may contribute to the pathogenesis of lung cancer by modulating EGFR-ERK signaling.http://europepmc.org/articles/PMC4029748?pdf=render |
| spellingShingle | Ying Yang Wei Zhao Qing-Wen Xu Xiao-Song Wang Yu Zhang Jun Zhang IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. PLoS ONE |
| title | IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. |
| title_full | IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. |
| title_fullStr | IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. |
| title_full_unstemmed | IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. |
| title_short | IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. |
| title_sort | iqgap3 promotes egfr erk signaling and the growth and metastasis of lung cancer cells |
| url | http://europepmc.org/articles/PMC4029748?pdf=render |
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