IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells.

IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells.

Proteins of the IQGAP family display complicated and often contradictory activities in tumorigenesis. IQGAP1 has well documented oncogenic potential and IQGAP2 has putative tumor-suppressive function. IQGAP3 is the latest addition to this family and its role in cancer development remains to be defin...

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Bibliographic Details
Main Authors: Ying Yang, Wei Zhao, Qing-Wen Xu, Xiao-Song Wang, Yu Zhang, Jun Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4029748?pdf=render

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