Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression
Oxidative stress and inflammation play an important role in the pathophysiological changes of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that positively regulates the basal and inducible expression of a large battery of cytoprotective genes, thus pla...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/8/1491 |
| _version_ | 1797585667113353216 |
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| author | Marina Fuertes-Agudo María Luque-Tévar Carme Cucarella Paloma Martín-Sanz Marta Casado |
| author_facet | Marina Fuertes-Agudo María Luque-Tévar Carme Cucarella Paloma Martín-Sanz Marta Casado |
| author_sort | Marina Fuertes-Agudo |
| collection | DOAJ |
| description | Oxidative stress and inflammation play an important role in the pathophysiological changes of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that positively regulates the basal and inducible expression of a large battery of cytoprotective genes, thus playing a key role in protecting against oxidative damage. Cyclooxygenase-2 (COX-2) is a key enzyme in prostaglandin biosynthesis. Its expression has always been associated with the induction of inflammation, but we have shown that, in addition to possessing other benefits, the constitutive expression of COX-2 in hepatocytes is beneficial in reducing inflammation and oxidative stress in multiple liver diseases. In this review, we summarized the role of NRF2 as a main agent in the resolution of oxidative stress, the crucial role of NRF2 signaling pathways during the development of chronic liver diseases, and, finally we related its action to that of COX-2, where it appears to operate as its partner in providing a hepatoprotective effect. |
| first_indexed | 2024-03-11T00:10:20Z |
| format | Article |
| id | doaj.art-3411cbcccb0247cda44bf1ff0e01ab6b |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T00:10:20Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3411cbcccb0247cda44bf1ff0e01ab6b2023-11-19T00:00:36ZengMDPI AGAntioxidants2076-39212023-07-01128149110.3390/antiox12081491Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 ExpressionMarina Fuertes-Agudo0María Luque-Tévar1Carme Cucarella2Paloma Martín-Sanz3Marta Casado4Instituto de Biomedicina de Valencia (IBV), CSIC, Jaume Roig 11, 46010 Valencia, SpainInstituto de Biomedicina de Valencia (IBV), CSIC, Jaume Roig 11, 46010 Valencia, SpainInstituto de Biomedicina de Valencia (IBV), CSIC, Jaume Roig 11, 46010 Valencia, SpainCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Monforte de Lemos 3-5, 28029 Madrid, SpainInstituto de Biomedicina de Valencia (IBV), CSIC, Jaume Roig 11, 46010 Valencia, SpainOxidative stress and inflammation play an important role in the pathophysiological changes of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that positively regulates the basal and inducible expression of a large battery of cytoprotective genes, thus playing a key role in protecting against oxidative damage. Cyclooxygenase-2 (COX-2) is a key enzyme in prostaglandin biosynthesis. Its expression has always been associated with the induction of inflammation, but we have shown that, in addition to possessing other benefits, the constitutive expression of COX-2 in hepatocytes is beneficial in reducing inflammation and oxidative stress in multiple liver diseases. In this review, we summarized the role of NRF2 as a main agent in the resolution of oxidative stress, the crucial role of NRF2 signaling pathways during the development of chronic liver diseases, and, finally we related its action to that of COX-2, where it appears to operate as its partner in providing a hepatoprotective effect.https://www.mdpi.com/2076-3921/12/8/1491liver diseasesNRF2COX-2oxidative stressinflammation |
| spellingShingle | Marina Fuertes-Agudo María Luque-Tévar Carme Cucarella Paloma Martín-Sanz Marta Casado Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression Antioxidants liver diseases NRF2 COX-2 oxidative stress inflammation |
| title | Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression |
| title_full | Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression |
| title_fullStr | Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression |
| title_full_unstemmed | Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression |
| title_short | Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression |
| title_sort | advances in understanding the role of nrf2 in liver pathophysiology and its relationship with hepatic specific cyclooxygenase 2 expression |
| topic | liver diseases NRF2 COX-2 oxidative stress inflammation |
| url | https://www.mdpi.com/2076-3921/12/8/1491 |
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