Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity
Background/Aims The aim of this study was to address the role of the elasticity index as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitatively assess shear wave elastography (SWE) as a tool for differentiating PTC from benign thyroid nodules. Methods One hun...
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The Korean Association of Internal Medicine
2019-07-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2016-326.pdf |
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| author | Hye Jeong Kim Mi Kyung Kwak In Ho Choi So-Young Jin Hyeong Kyu Park Dong Won Byun Kyoil Suh Myung Hi Yoo |
| author_facet | Hye Jeong Kim Mi Kyung Kwak In Ho Choi So-Young Jin Hyeong Kyu Park Dong Won Byun Kyoil Suh Myung Hi Yoo |
| author_sort | Hye Jeong Kim |
| collection | DOAJ |
| description | Background/Aims The aim of this study was to address the role of the elasticity index as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitatively assess shear wave elastography (SWE) as a tool for differentiating PTC from benign thyroid nodules. Methods One hundred and nineteen patients with thyroid nodules undergoing SWE before ultrasound-guided fine needle aspiration and core needle biopsy were analyzed. The mean (EMean), minimum (EMin), maximum (EMax), and standard deviation (ESD) of SWE elasticity indices were measured. Results Among 105 nodules, 14 were PTC and 91 were benign. The EMean, EMin, and EMax values were significantly higher in PTCs than benign nodules (EMean 37.4 in PTC vs. 23.7 in benign nodules, p = 0.005; EMin 27.9 vs. 17.8, p = 0.034; EMax 46.7 vs. 31.5, p < 0.001). The EMean, EMin, and EMax were significantly associated with PTC with diagnostic odds ratios varying from 6.74 to 9.91, high specificities (86.4%, 86.4%, and 88.1%, respectively), and positive likelihood ratios (4.21, 3.69, and 4.82, respectively). The ESD values were significantly higher in PTC than in benign nodules (6.3 vs. 2.6, p < 0.001). ESD had the highest specificity (96.6%) when applied with a cut-off value of 6.5 kPa. It had a positive likelihood ratio of 14.75 and a diagnostic odds ratio of 28.50. Conclusions The shear elasticity index of ESD, with higher likelihood ratios for PTC, will probably identify nodules that have a high potential for malignancy. It may help to identify and select malignant nodules, while reducing unnecessary fine needle aspiration and core needle biopsies of benign nodules. |
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| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-16T14:32:25Z |
| publishDate | 2019-07-01 |
| publisher | The Korean Association of Internal Medicine |
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| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-3411ea05a29a4f6b9d2320a743cf12f42022-12-21T22:28:11ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482019-07-0134485085710.3904/kjim.2016.326170026Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticityHye Jeong Kim0Mi Kyung Kwak1In Ho Choi2So-Young Jin3Hyeong Kyu Park4Dong Won Byun5Kyoil Suh6Myung Hi Yoo7 Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital Seoul, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital Seoul, Seoul, Korea Department of Pathology, Soonchunhyang University Seoul Hospital, Seoul, Korea Department of Pathology, Soonchunhyang University Seoul Hospital, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital Seoul, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital Seoul, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital Seoul, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital Seoul, Seoul, KoreaBackground/Aims The aim of this study was to address the role of the elasticity index as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitatively assess shear wave elastography (SWE) as a tool for differentiating PTC from benign thyroid nodules. Methods One hundred and nineteen patients with thyroid nodules undergoing SWE before ultrasound-guided fine needle aspiration and core needle biopsy were analyzed. The mean (EMean), minimum (EMin), maximum (EMax), and standard deviation (ESD) of SWE elasticity indices were measured. Results Among 105 nodules, 14 were PTC and 91 were benign. The EMean, EMin, and EMax values were significantly higher in PTCs than benign nodules (EMean 37.4 in PTC vs. 23.7 in benign nodules, p = 0.005; EMin 27.9 vs. 17.8, p = 0.034; EMax 46.7 vs. 31.5, p < 0.001). The EMean, EMin, and EMax were significantly associated with PTC with diagnostic odds ratios varying from 6.74 to 9.91, high specificities (86.4%, 86.4%, and 88.1%, respectively), and positive likelihood ratios (4.21, 3.69, and 4.82, respectively). The ESD values were significantly higher in PTC than in benign nodules (6.3 vs. 2.6, p < 0.001). ESD had the highest specificity (96.6%) when applied with a cut-off value of 6.5 kPa. It had a positive likelihood ratio of 14.75 and a diagnostic odds ratio of 28.50. Conclusions The shear elasticity index of ESD, with higher likelihood ratios for PTC, will probably identify nodules that have a high potential for malignancy. It may help to identify and select malignant nodules, while reducing unnecessary fine needle aspiration and core needle biopsies of benign nodules.http://www.kjim.org/upload/pdf/kjim-2016-326.pdfelasticity imaging techniquesshear wavethyroid cancer, papillarythyroid nodule |
| spellingShingle | Hye Jeong Kim Mi Kyung Kwak In Ho Choi So-Young Jin Hyeong Kyu Park Dong Won Byun Kyoil Suh Myung Hi Yoo Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity The Korean Journal of Internal Medicine elasticity imaging techniques shear wave thyroid cancer, papillary thyroid nodule |
| title | Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity |
| title_full | Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity |
| title_fullStr | Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity |
| title_full_unstemmed | Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity |
| title_short | Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity |
| title_sort | utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules efficacy of the standard deviation elasticity |
| topic | elasticity imaging techniques shear wave thyroid cancer, papillary thyroid nodule |
| url | http://www.kjim.org/upload/pdf/kjim-2016-326.pdf |
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