Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial
Aim: This study is aimed to evaluate the effects of boron on radiation-induced skin reactions (RISR) in breast cancer patients. Material and methods: After 47 patients with invasive ductal carcinoma underwent radiotherapy, 23 (49%) received a boron-based gel, and 24 (51%) received placebo. Assessmen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-05-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2016.1232449 |
| _version_ | 1797684592595959808 |
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| author | Erhan Aysan Ufuk Oguz Idiz Leyla Elmas Esra Kaytan Saglam Zuleyha Akgun Serap Baskaya Yucel |
| author_facet | Erhan Aysan Ufuk Oguz Idiz Leyla Elmas Esra Kaytan Saglam Zuleyha Akgun Serap Baskaya Yucel |
| author_sort | Erhan Aysan |
| collection | DOAJ |
| description | Aim: This study is aimed to evaluate the effects of boron on radiation-induced skin reactions (RISR) in breast cancer patients. Material and methods: After 47 patients with invasive ductal carcinoma underwent radiotherapy, 23 (49%) received a boron-based gel, and 24 (51%) received placebo. Assessments were performed according to the Radiation Therapy Oncology Group (RTOG) skin scale and a Five-Point Horizontal Scale (FPHS). Results: At the end of the fifth week of radiotherapy, the RTOG scores in the boron group were significantly lower than those in the placebo group (p = .024). The FPHS score was higher in the placebo group than in the boron group, and this difference was not statistically significant (p = .079). Conclusion: Using the RTOG scoring system, we revealed that the application of a boron-based gel diminished RISR. The mechanism of action is unclear but may be related to antioxidant, wound healing, and thermal degradation effects of boron. |
| first_indexed | 2024-03-12T00:32:00Z |
| format | Article |
| id | doaj.art-3411f076f86240a7a77f63e254ac78fa |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:32:00Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-3411f076f86240a7a77f63e254ac78fa2023-09-15T10:12:26ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532017-05-0130318719210.1080/08941939.2016.12324491232449Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled TrialErhan Aysan0Ufuk Oguz Idiz1Leyla Elmas2Esra Kaytan Saglam3Zuleyha Akgun4Serap Baskaya Yucel5Bezmialem Vakif UniversitySisli Etfal Training and Research HospitalBezmialem Vakif UniversityBezmialem Vakif UniversityBezmialem Vakif UniversityBezmialem Vakif UniversityAim: This study is aimed to evaluate the effects of boron on radiation-induced skin reactions (RISR) in breast cancer patients. Material and methods: After 47 patients with invasive ductal carcinoma underwent radiotherapy, 23 (49%) received a boron-based gel, and 24 (51%) received placebo. Assessments were performed according to the Radiation Therapy Oncology Group (RTOG) skin scale and a Five-Point Horizontal Scale (FPHS). Results: At the end of the fifth week of radiotherapy, the RTOG scores in the boron group were significantly lower than those in the placebo group (p = .024). The FPHS score was higher in the placebo group than in the boron group, and this difference was not statistically significant (p = .079). Conclusion: Using the RTOG scoring system, we revealed that the application of a boron-based gel diminished RISR. The mechanism of action is unclear but may be related to antioxidant, wound healing, and thermal degradation effects of boron.http://dx.doi.org/10.1080/08941939.2016.1232449boronbreastcancerradiationdermatitisgel |
| spellingShingle | Erhan Aysan Ufuk Oguz Idiz Leyla Elmas Esra Kaytan Saglam Zuleyha Akgun Serap Baskaya Yucel Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial Journal of Investigative Surgery boron breast cancer radiation dermatitis gel |
| title | Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial |
| title_full | Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial |
| title_fullStr | Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial |
| title_full_unstemmed | Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial |
| title_short | Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial |
| title_sort | effects of boron based gel on radiation induced dermatitis in breast cancer a double blind placebo controlled trial |
| topic | boron breast cancer radiation dermatitis gel |
| url | http://dx.doi.org/10.1080/08941939.2016.1232449 |
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