D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect

D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect

The crown of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is constituted by its spike (S) glycoprotein. S protein mediates the SARS-CoV-2 entry into the host cells. The “fusion core” of the heptad repeat 1 (HR1) on S plays a crucial role in the virus infectivity, as it is part of...

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Bibliographic Details
Main Authors: Romina Oliva, Abdul Rajjak Shaikh, Andrea Petta, Anna Vangone, Luigi Cavallo
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
COVID-19
spike protein
mutations
molecular dynamics
infectivity
Online Access:https://www.mdpi.com/1420-3049/26/9/2622

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