Graft Strategy for Coronary Artery Bypass Grafting in Patients with Severe Left Ventricular Dysfunction
Background: Optimal graft selection for coronary artery bypass grafting (CABG) in patients with severe left ventricular (LV) dysfunction remains debatable. We report an analysis of our experiences of isolated CABG in patients with severe LV dysfunction and the impact of graft strategy on long-term o...
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| Format: | Article |
| Language: | English |
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Korean Society for Thoracic and Cardiovascular Surgery
2019-02-01
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| Series: | Korean Journal of Thoracic and Cardiovascular Surgery |
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| _version_ | 1819155346612027392 |
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| author | Tae Hee Hong You Jin Ha Dong Seop Jeong Wook Sung Kim Young Tak Lee |
| author_facet | Tae Hee Hong You Jin Ha Dong Seop Jeong Wook Sung Kim Young Tak Lee |
| author_sort | Tae Hee Hong |
| collection | DOAJ |
| description | Background: Optimal graft selection for coronary artery bypass grafting (CABG) in patients with severe left ventricular (LV) dysfunction remains debatable. We report an analysis of our experiences of isolated CABG in patients with severe LV dysfunction and the impact of graft strategy on long-term outcomes. Methods: We analyzed 209 patients with severe LV dysfunction (ejection fraction [EF] ＜30%) who underwent primary isolated CABG. Of these, 169 were revascularized with a bilateral internal thoracic arterial (ITA) graft (BITA group) and 40 were revascularized with a single ITA graft (SITA group). The mean follow-up duration was 22±32 months. Results: There were 18 early deaths (8.6%). Overall survival at 5 years was 66.7%. The rate of freedom from cardiac-related death at 5 years was 74.1%, and was significantly higher in patients who underwent off-pump CABG (p=0.005) and in the BITA group (p=0.023). Multivariate analysis demonstrated that old age (hazard ratio [HR], 2.548; 95% confidence interval [CI], 1.134–5.762; p=0.024), off-pump CABG
(HR, 0.245; 95% CI, 0.090–0.661; p=0.006), and BITA grafts (HR, 0.333; 95% CI, 0.146–0.757; p=0.009) were correlated with cardiac mortality. Conclusion: CABG in patients with severe LV dysfunction (EF ＜30%) showed reasonable long-term outcomes. The rate of freedom from cardiac-related death was significantly higher in patients who underwent off-pump CABG and in the BITA group. Off-pump BITA grafting strategies can be accepted as a viable primary option in patients with severe LV dysfunction if performed by an experienced surgeon. |
| first_indexed | 2024-12-22T15:35:31Z |
| format | Article |
| id | doaj.art-3413d4f0064d4a5aae8b471b25f734cf |
| institution | Directory Open Access Journal |
| issn | 2233-601X 2093-6516 |
| language | English |
| last_indexed | 2024-12-22T15:35:31Z |
| publishDate | 2019-02-01 |
| publisher | Korean Society for Thoracic and Cardiovascular Surgery |
| record_format | Article |
| series | Korean Journal of Thoracic and Cardiovascular Surgery |
| spelling | doaj.art-3413d4f0064d4a5aae8b471b25f734cf2022-12-21T18:21:16ZengKorean Society for Thoracic and Cardiovascular SurgeryKorean Journal of Thoracic and Cardiovascular Surgery2233-601X2093-65162019-02-01521162410.5090/kjtcs.2019.52.1.16Graft Strategy for Coronary Artery Bypass Grafting in Patients with Severe Left Ventricular DysfunctionTae Hee Hong0You Jin Ha1Dong Seop Jeong2Wook Sung Kim3Young Tak Lee4Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of MedicineBackground: Optimal graft selection for coronary artery bypass grafting (CABG) in patients with severe left ventricular (LV) dysfunction remains debatable. We report an analysis of our experiences of isolated CABG in patients with severe LV dysfunction and the impact of graft strategy on long-term outcomes. Methods: We analyzed 209 patients with severe LV dysfunction (ejection fraction [EF] ＜30%) who underwent primary isolated CABG. Of these, 169 were revascularized with a bilateral internal thoracic arterial (ITA) graft (BITA group) and 40 were revascularized with a single ITA graft (SITA group). The mean follow-up duration was 22±32 months. Results: There were 18 early deaths (8.6%). Overall survival at 5 years was 66.7%. The rate of freedom from cardiac-related death at 5 years was 74.1%, and was significantly higher in patients who underwent off-pump CABG (p=0.005) and in the BITA group (p=0.023). Multivariate analysis demonstrated that old age (hazard ratio [HR], 2.548; 95% confidence interval [CI], 1.134–5.762; p=0.024), off-pump CABG (HR, 0.245; 95% CI, 0.090–0.661; p=0.006), and BITA grafts (HR, 0.333; 95% CI, 0.146–0.757; p=0.009) were correlated with cardiac mortality. Conclusion: CABG in patients with severe LV dysfunction (EF ＜30%) showed reasonable long-term outcomes. The rate of freedom from cardiac-related death was significantly higher in patients who underwent off-pump CABG and in the BITA group. Off-pump BITA grafting strategies can be accepted as a viable primary option in patients with severe LV dysfunction if performed by an experienced surgeon.Coronary artery bypassCardiomyopathiesMammary arteries |
| spellingShingle | Tae Hee Hong You Jin Ha Dong Seop Jeong Wook Sung Kim Young Tak Lee Graft Strategy for Coronary Artery Bypass Grafting in Patients with Severe Left Ventricular Dysfunction Korean Journal of Thoracic and Cardiovascular Surgery Coronary artery bypass Cardiomyopathies Mammary arteries |
| title | Graft Strategy for Coronary Artery Bypass Grafting in Patients with Severe Left Ventricular Dysfunction |
| title_full | Graft Strategy for Coronary Artery Bypass Grafting in Patients with Severe Left Ventricular Dysfunction |
| title_fullStr | Graft Strategy for Coronary Artery Bypass Grafting in Patients with Severe Left Ventricular Dysfunction |
| title_full_unstemmed | Graft Strategy for Coronary Artery Bypass Grafting in Patients with Severe Left Ventricular Dysfunction |
| title_short | Graft Strategy for Coronary Artery Bypass Grafting in Patients with Severe Left Ventricular Dysfunction |
| title_sort | graft strategy for coronary artery bypass grafting in patients with severe left ventricular dysfunction |
| topic | Coronary artery bypass Cardiomyopathies Mammary arteries |
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