Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers
The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irrep...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.598817/full |
| _version_ | 1819061682593333248 |
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| author | Na Gao Yueheng Li Jing Li Zhengfan Gao Zhenzhen Yang Zhenzhen Yang Yong Li Yong Li Hongtao Liu Tianli Fan |
| author_facet | Na Gao Yueheng Li Jing Li Zhengfan Gao Zhenzhen Yang Zhenzhen Yang Yong Li Yong Li Hongtao Liu Tianli Fan |
| author_sort | Na Gao |
| collection | DOAJ |
| description | The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irreplaceable role in tumor initiation, progression, as well as metastasis, and are novel molecular biomarkers for diagnosis and prognosis of cancer patients. Furthermore, lncRNAs and the pathways they influence might represent promising therapeutic targets for a number of tumors. Here, we discuss the recent advances in understanding of the specific regulatory mechanisms of lncRNAs. We focused on the signal, decoy, guide, and scaffold functions of lncRNAs at the epigenetic, transcription, and post-transcription levels in cancer cells. Additionally, we summarize the research strategies used to investigate the roles of lncRNAs in tumors, including lncRNAs screening, lncRNAs characteristic analyses, functional studies, and molecular mechanisms of lncRNAs. This review will provide a short but comprehensive description of the lncRNA functions in tumor development and progression, thus accelerating the clinical implementation of lncRNAs as tumor biomarkers and therapeutic targets. |
| first_indexed | 2024-12-21T14:46:46Z |
| format | Article |
| id | doaj.art-3414deaa2881461082ba55d47d4c6919 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T14:46:46Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3414deaa2881461082ba55d47d4c69192022-12-21T18:59:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.598817598817Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in CancersNa Gao0Yueheng Li1Jing Li2Zhengfan Gao3Zhenzhen Yang4Zhenzhen Yang5Yong Li6Yong Li7Hongtao Liu8Tianli Fan9Department of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaTranslational Medicine Research Center, People’s Hospital of Zhengzhou, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaFaculty of Medicine, St George and Sutherland Clinical School, St George Hospital, The University of New South Wales (UNSW) Sydney, Kensington, NSW, AustraliaLaboratory for Cell Biology, College of Life Sciences of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaThe development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irreplaceable role in tumor initiation, progression, as well as metastasis, and are novel molecular biomarkers for diagnosis and prognosis of cancer patients. Furthermore, lncRNAs and the pathways they influence might represent promising therapeutic targets for a number of tumors. Here, we discuss the recent advances in understanding of the specific regulatory mechanisms of lncRNAs. We focused on the signal, decoy, guide, and scaffold functions of lncRNAs at the epigenetic, transcription, and post-transcription levels in cancer cells. Additionally, we summarize the research strategies used to investigate the roles of lncRNAs in tumors, including lncRNAs screening, lncRNAs characteristic analyses, functional studies, and molecular mechanisms of lncRNAs. This review will provide a short but comprehensive description of the lncRNA functions in tumor development and progression, thus accelerating the clinical implementation of lncRNAs as tumor biomarkers and therapeutic targets.https://www.frontiersin.org/articles/10.3389/fonc.2020.598817/fulllong non-coding RNAmechanism of actionresearch strategiestherapeutic targetscancer |
| spellingShingle | Na Gao Yueheng Li Jing Li Zhengfan Gao Zhenzhen Yang Zhenzhen Yang Yong Li Yong Li Hongtao Liu Tianli Fan Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers Frontiers in Oncology long non-coding RNA mechanism of action research strategies therapeutic targets cancer |
| title | Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers |
| title_full | Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers |
| title_fullStr | Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers |
| title_full_unstemmed | Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers |
| title_short | Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers |
| title_sort | long non coding rnas the regulatory mechanisms research strategies and future directions in cancers |
| topic | long non-coding RNA mechanism of action research strategies therapeutic targets cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.598817/full |
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