Systems mapping of HIV-1 infection
<p>Abstract</p> <p>Mathematical models of viral dynamics <it>in vivo</it> provide incredible insights into the mechanisms for the nonlinear interaction between virus and host cell populations, the dynamics of viral drug resistance, and the way to eliminate virus infecti...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-10-01
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| Series: | BMC Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2156/13/91 |
| Summary: | <p>Abstract</p> <p>Mathematical models of viral dynamics <it>in vivo</it> provide incredible insights into the mechanisms for the nonlinear interaction between virus and host cell populations, the dynamics of viral drug resistance, and the way to eliminate virus infection from individual patients by drug treatment. The integration of these mathematical models with high-throughput genetic and genomic data within a statistical framework will raise a hope for effective treatment of infections with HIV virus through developing potent antiviral drugs based on individual patients’ genetic makeup. In this opinion article, we will show a conceptual model for mapping and dictating a comprehensive picture of genetic control mechanisms for viral dynamics through incorporating a group of differential equations that quantify the emergent properties of a system.</p> |
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| ISSN: | 1471-2156 |