The Synthesis of Biphasic Metabolites of Carfentanil
Carfentanil is an ultra-potent synthetic opioid. The Russian police force used both carfentanil and remifentanil to resolve a hostage incident in Moscow. This reported use sparked an interest in the pharmacology and toxicology of carfentanil in the human body, and data on its metabolites were later...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/22/7625 |
| _version_ | 1797458228815069184 |
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| author | Junchang Wang Jianwen Hu Pingyong Liao Shang Xue Shan He Ruijia Chen Xuejun Zhao Wenbin Liu |
| author_facet | Junchang Wang Jianwen Hu Pingyong Liao Shang Xue Shan He Ruijia Chen Xuejun Zhao Wenbin Liu |
| author_sort | Junchang Wang |
| collection | DOAJ |
| description | Carfentanil is an ultra-potent synthetic opioid. The Russian police force used both carfentanil and remifentanil to resolve a hostage incident in Moscow. This reported use sparked an interest in the pharmacology and toxicology of carfentanil in the human body, and data on its metabolites were later published. However, there have been few studies on the synthesis of carfentanil metabolites, and biological extraction has also put forward large uncertainty in subsequent studies. The aim of the present study is to investigate the synthesis of biphasic metabolites that are unique to carfentanil. The purpose was to produce corresponding metabolites conveniently, quickly, and at low cost that can be used for comparison with published structures and to confirm the administration of carfentanil. |
| first_indexed | 2024-03-09T16:34:06Z |
| format | Article |
| id | doaj.art-34163c71a98748ea96392efaf612126a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T16:34:06Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-34163c71a98748ea96392efaf612126a2023-11-24T14:58:28ZengMDPI AGMolecules1420-30492023-11-012822762510.3390/molecules28227625The Synthesis of Biphasic Metabolites of CarfentanilJunchang Wang0Jianwen Hu1Pingyong Liao2Shang Xue3Shan He4Ruijia Chen5Xuejun Zhao6Wenbin Liu7Shanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, ChinaShanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, ChinaShanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, ChinaShanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, ChinaShanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, ChinaShanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, ChinaShanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, ChinaShanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, ChinaCarfentanil is an ultra-potent synthetic opioid. The Russian police force used both carfentanil and remifentanil to resolve a hostage incident in Moscow. This reported use sparked an interest in the pharmacology and toxicology of carfentanil in the human body, and data on its metabolites were later published. However, there have been few studies on the synthesis of carfentanil metabolites, and biological extraction has also put forward large uncertainty in subsequent studies. The aim of the present study is to investigate the synthesis of biphasic metabolites that are unique to carfentanil. The purpose was to produce corresponding metabolites conveniently, quickly, and at low cost that can be used for comparison with published structures and to confirm the administration of carfentanil.https://www.mdpi.com/1420-3049/28/22/7625carfentanilmetabolismcarbohydrateglycoconjugates |
| spellingShingle | Junchang Wang Jianwen Hu Pingyong Liao Shang Xue Shan He Ruijia Chen Xuejun Zhao Wenbin Liu The Synthesis of Biphasic Metabolites of Carfentanil Molecules carfentanil metabolism carbohydrate glycoconjugates |
| title | The Synthesis of Biphasic Metabolites of Carfentanil |
| title_full | The Synthesis of Biphasic Metabolites of Carfentanil |
| title_fullStr | The Synthesis of Biphasic Metabolites of Carfentanil |
| title_full_unstemmed | The Synthesis of Biphasic Metabolites of Carfentanil |
| title_short | The Synthesis of Biphasic Metabolites of Carfentanil |
| title_sort | synthesis of biphasic metabolites of carfentanil |
| topic | carfentanil metabolism carbohydrate glycoconjugates |
| url | https://www.mdpi.com/1420-3049/28/22/7625 |
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