Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer
Ovarian cancer is the seventh most common cancer in women worldwide and the eighth most common cause of cancer death. Due to the lack of effective early detection strategies and the unspecific onset of symptoms, it is diagnosed at an advanced stage in 75% of cases. The cancer antigen (CA) 125 is use...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2021-08-01
|
| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/raon-2021-0013 |
| _version_ | 1797848556002869248 |
|---|---|
| author | Merlo Sebastjan Besic Nikola Drmota Eva Kovacevic Nina |
| author_facet | Merlo Sebastjan Besic Nikola Drmota Eva Kovacevic Nina |
| author_sort | Merlo Sebastjan |
| collection | DOAJ |
| description | Ovarian cancer is the seventh most common cancer in women worldwide and the eighth most common cause of cancer death. Due to the lack of effective early detection strategies and the unspecific onset of symptoms, it is diagnosed at an advanced stage in 75% of cases. The cancer antigen (CA) 125 is used as a prognostic marker and its level is elevated in more than 85% of women with advanced stages of epithelial ovarian cancer (EOC). The standard treatment is primary debulking surgery (PDS) followed by adjuvant chemotherapy (ACT), but the later approach is neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). Several studies have been conducted to find out whether preoperative CA-125 serum levels influence treatment choice, surgical resection and survival outcome. The aim of our study was to analyse experience of single institution as Cancer comprehensive center with preoperative usefulness of CA-125. |
| first_indexed | 2024-04-09T18:29:34Z |
| format | Article |
| id | doaj.art-34178df50b164b7eace657ea8d075c6f |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-04-09T18:29:34Z |
| publishDate | 2021-08-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-34178df50b164b7eace657ea8d075c6f2023-04-11T17:19:27ZengSciendoRadiology and Oncology1581-32072021-08-0155334134610.2478/raon-2021-0013Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancerMerlo Sebastjan0Besic Nikola1Drmota Eva2Kovacevic Nina3Department of Gynaecological Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaDepartment of Gynaecological Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaOvarian cancer is the seventh most common cancer in women worldwide and the eighth most common cause of cancer death. Due to the lack of effective early detection strategies and the unspecific onset of symptoms, it is diagnosed at an advanced stage in 75% of cases. The cancer antigen (CA) 125 is used as a prognostic marker and its level is elevated in more than 85% of women with advanced stages of epithelial ovarian cancer (EOC). The standard treatment is primary debulking surgery (PDS) followed by adjuvant chemotherapy (ACT), but the later approach is neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). Several studies have been conducted to find out whether preoperative CA-125 serum levels influence treatment choice, surgical resection and survival outcome. The aim of our study was to analyse experience of single institution as Cancer comprehensive center with preoperative usefulness of CA-125.https://doi.org/10.2478/raon-2021-0013ovarian cancertumour markerca-125primary debulking surgeryneoadjuvant chemotherapy |
| spellingShingle | Merlo Sebastjan Besic Nikola Drmota Eva Kovacevic Nina Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer Radiology and Oncology ovarian cancer tumour marker ca-125 primary debulking surgery neoadjuvant chemotherapy |
| title | Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer |
| title_full | Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer |
| title_fullStr | Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer |
| title_full_unstemmed | Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer |
| title_short | Preoperative serum CA-125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer |
| title_sort | preoperative serum ca 125 level as a predictor for the extent of cytoreduction in patients with advanced stage epithelial ovarian cancer |
| topic | ovarian cancer tumour marker ca-125 primary debulking surgery neoadjuvant chemotherapy |
| url | https://doi.org/10.2478/raon-2021-0013 |
| work_keys_str_mv | AT merlosebastjan preoperativeserumca125levelasapredictorfortheextentofcytoreductioninpatientswithadvancedstageepithelialovariancancer AT besicnikola preoperativeserumca125levelasapredictorfortheextentofcytoreductioninpatientswithadvancedstageepithelialovariancancer AT drmotaeva preoperativeserumca125levelasapredictorfortheextentofcytoreductioninpatientswithadvancedstageepithelialovariancancer AT kovacevicnina preoperativeserumca125levelasapredictorfortheextentofcytoreductioninpatientswithadvancedstageepithelialovariancancer |