Ethnic differences in mammographic densities: an Asian cross-sectional study.
BACKGROUND:Mammographic density is a strong risk factor for breast cancer and is highly variable, but, to date, few studies have examined density in Asian women, particularly those in low and middle-income Asian countries where genetic and lifestyle determinants may be significantly different. METHO...
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| Format: | Article |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4320072?pdf=render |
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| author | Shivaani Mariapun Jingmei Li Cheng Har Yip Nur Aishah Mohd Taib Soo-Hwang Teo |
| author_facet | Shivaani Mariapun Jingmei Li Cheng Har Yip Nur Aishah Mohd Taib Soo-Hwang Teo |
| author_sort | Shivaani Mariapun |
| collection | DOAJ |
| description | BACKGROUND:Mammographic density is a strong risk factor for breast cancer and is highly variable, but, to date, few studies have examined density in Asian women, particularly those in low and middle-income Asian countries where genetic and lifestyle determinants may be significantly different. METHODS:A total of 1,240 women who attended an opportunistic mammogram screening programme were eligible for analysis. Mammographic density was estimated using a fully-automated thresholding method and differences across ethnic groups were examined using linear regression in 205 randomly selected Chinese women, 138 Malay and 199 Indian women. RESULTS:Percent density was significantly higher in Chinese women (28.5%; 95% CI 27.0%, 30.0%) compared to Malay (24.2%; 95% CI 22.5%, 26.0%) and Indian (24.3%; 95% CI 22.8%, 25.7%) women (p<0.001), after adjustment for age, BMI, menopausal status, parity and age at first full term pregnancy. Correspondingly, adjusted nondense area was significantly lower in Chinese (72.2cm2; 95% CI 67.9cm2, 76.5cm2) women compared to Malay (92.1cm2; 95% CI 86.9cm2, 97.2cm2) and Indian (97.7cm2; 95% CI 93.4cm2, 101.9cm2) women (p<0.001), but dense area did not differ across the three ethnic groups. CONCLUSIONS:Our study shows that higher percent density and lower nondense area reflect the higher incidence of breast cancer in Chinese compared to Malay and Indian women in Malaysia. Known lifestyle determinants of mammographic density do not fully account for the ethnic variations observed in mammographic density in this Asian cohort. |
| first_indexed | 2024-04-12T09:28:50Z |
| format | Article |
| id | doaj.art-34184c9d755e4fa0b73ecb0063d26bbc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T09:28:50Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-34184c9d755e4fa0b73ecb0063d26bbc2022-12-22T03:38:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011756810.1371/journal.pone.0117568Ethnic differences in mammographic densities: an Asian cross-sectional study.Shivaani MariapunJingmei LiCheng Har YipNur Aishah Mohd TaibSoo-Hwang TeoBACKGROUND:Mammographic density is a strong risk factor for breast cancer and is highly variable, but, to date, few studies have examined density in Asian women, particularly those in low and middle-income Asian countries where genetic and lifestyle determinants may be significantly different. METHODS:A total of 1,240 women who attended an opportunistic mammogram screening programme were eligible for analysis. Mammographic density was estimated using a fully-automated thresholding method and differences across ethnic groups were examined using linear regression in 205 randomly selected Chinese women, 138 Malay and 199 Indian women. RESULTS:Percent density was significantly higher in Chinese women (28.5%; 95% CI 27.0%, 30.0%) compared to Malay (24.2%; 95% CI 22.5%, 26.0%) and Indian (24.3%; 95% CI 22.8%, 25.7%) women (p<0.001), after adjustment for age, BMI, menopausal status, parity and age at first full term pregnancy. Correspondingly, adjusted nondense area was significantly lower in Chinese (72.2cm2; 95% CI 67.9cm2, 76.5cm2) women compared to Malay (92.1cm2; 95% CI 86.9cm2, 97.2cm2) and Indian (97.7cm2; 95% CI 93.4cm2, 101.9cm2) women (p<0.001), but dense area did not differ across the three ethnic groups. CONCLUSIONS:Our study shows that higher percent density and lower nondense area reflect the higher incidence of breast cancer in Chinese compared to Malay and Indian women in Malaysia. Known lifestyle determinants of mammographic density do not fully account for the ethnic variations observed in mammographic density in this Asian cohort.http://europepmc.org/articles/PMC4320072?pdf=render |
| spellingShingle | Shivaani Mariapun Jingmei Li Cheng Har Yip Nur Aishah Mohd Taib Soo-Hwang Teo Ethnic differences in mammographic densities: an Asian cross-sectional study. PLoS ONE |
| title | Ethnic differences in mammographic densities: an Asian cross-sectional study. |
| title_full | Ethnic differences in mammographic densities: an Asian cross-sectional study. |
| title_fullStr | Ethnic differences in mammographic densities: an Asian cross-sectional study. |
| title_full_unstemmed | Ethnic differences in mammographic densities: an Asian cross-sectional study. |
| title_short | Ethnic differences in mammographic densities: an Asian cross-sectional study. |
| title_sort | ethnic differences in mammographic densities an asian cross sectional study |
| url | http://europepmc.org/articles/PMC4320072?pdf=render |
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