Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate

Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate

Progressive decline in pancreatic beta-cell function is central to the pathogenesis of type 2 diabetes (T2D). Here, we explore the relationship between the beta cell and its nutritional environment, asking how an excess of energy substrate leads to altered energy production and subsequent insulin se...

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Bibliographic Details
Main Authors: Johan Perrier, Margaux Nawrot, Anne-Marie Madec, Karim Chikh, Marie-Agnès Chauvin, Christian Damblon, Julia Sabatier, Charles H. Thivolet, Jennifer Rieusset, Gilles J. P. Rautureau, Baptiste Panthu
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Nutrients
Subjects:
human pancreatic islets
INS-1E
NMR
glucolipotoxicity
GSIS
insulin content
Online Access:https://www.mdpi.com/2072-6643/15/22/4791

Internet

https://www.mdpi.com/2072-6643/15/22/4791

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