Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode
The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry. Metformin hydrochloride shows an irreversible oxidation behavior at all...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2015-07-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/950 |
| Summary: | The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry. Metformin hydrochloride shows an irreversible oxidation behavior at all pH values of Britton-Robinson buffer (2.0-9.0). The peak current varied linearly in the range comprised between 8.0 x 10-7 and 6.0 x 10-6 mol/Lwith detection limit of 6.63 x 10-8 mol/Land limit of quantification of 2.21 x 10-7 mol/L. The method was proposed for the determination of metformin hydrochloride in dosage forms and urine. |
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| ISSN: | 1318-0207 1580-3155 |