Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode
The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry. Metformin hydrochloride shows an irreversible oxidation behavior at all...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Chemical Society
2015-07-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/950 |
| _version_ | 1818274617671811072 |
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| author | Ali Kamal Attia Waheed M Salem Mona A Mohamed |
| author_facet | Ali Kamal Attia Waheed M Salem Mona A Mohamed |
| author_sort | Ali Kamal Attia |
| collection | DOAJ |
| description | The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry. Metformin hydrochloride shows an irreversible oxidation behavior at all pH values of Britton-Robinson buffer (2.0-9.0). The peak current varied linearly in the range comprised between 8.0 x 10-7 and 6.0 x 10-6 mol/Lwith detection limit of 6.63 x 10-8 mol/Land limit of quantification of 2.21 x 10-7 mol/L. The method was proposed for the determination of metformin hydrochloride in dosage forms and urine. |
| first_indexed | 2024-12-12T22:16:43Z |
| format | Article |
| id | doaj.art-341adf4282fa499c95efb73a676e0705 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-12T22:16:43Z |
| publishDate | 2015-07-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-341adf4282fa499c95efb73a676e07052022-12-22T00:10:03ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552015-07-0162358859410.17344/acsi.2014.950258Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste ElectrodeAli Kamal Attia0Waheed M SalemMona A MohamedNational Organization for Drug Control and Research (NODCAR)The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry. Metformin hydrochloride shows an irreversible oxidation behavior at all pH values of Britton-Robinson buffer (2.0-9.0). The peak current varied linearly in the range comprised between 8.0 x 10-7 and 6.0 x 10-6 mol/Lwith detection limit of 6.63 x 10-8 mol/Land limit of quantification of 2.21 x 10-7 mol/L. The method was proposed for the determination of metformin hydrochloride in dosage forms and urine.https://journals.matheo.si/index.php/ACSi/article/view/950MetforminModified electrodeVoltammetryUrine |
| spellingShingle | Ali Kamal Attia Waheed M Salem Mona A Mohamed Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode Acta Chimica Slovenica Metformin Modified electrode Voltammetry Urine |
| title | Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode |
| title_full | Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode |
| title_fullStr | Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode |
| title_full_unstemmed | Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode |
| title_short | Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode |
| title_sort | voltammetric assay of metformin hydrochloride using pyrogallol modified carbon paste electrode |
| topic | Metformin Modified electrode Voltammetry Urine |
| url | https://journals.matheo.si/index.php/ACSi/article/view/950 |
| work_keys_str_mv | AT alikamalattia voltammetricassayofmetforminhydrochlorideusingpyrogallolmodifiedcarbonpasteelectrode AT waheedmsalem voltammetricassayofmetforminhydrochlorideusingpyrogallolmodifiedcarbonpasteelectrode AT monaamohamed voltammetricassayofmetforminhydrochlorideusingpyrogallolmodifiedcarbonpasteelectrode |