CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere?
The CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been extensively studied, mainly in colorectal cancers (CRC) and gliomas. Consequently, knowledge on molecular and pathologica...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/2/830 |
| _version_ | 1797493287636959232 |
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| author | Karpiński Paweł Sąsiadek Maria Małgorzata |
| author_facet | Karpiński Paweł Sąsiadek Maria Małgorzata |
| author_sort | Karpiński Paweł |
| collection | DOAJ |
| description | The CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been extensively studied, mainly in colorectal cancers (CRC) and gliomas. Consequently, knowledge on molecular and pathological characteristics of CIMP in CRC and other tumour types has rapidly expanded. Concordant and widespread hypermethylation of multiple CpG islands observed in CIMP in multiple cancers raised hopes for future epigenetically based diagnostics and treatments of solid tumours. However, studies on CIMP in solid tumours were hampered by a lack of generalisability and reproducibility of epigenetic markers. Moreover, CIMP was not a satisfactory marker in predicting clinical outcomes. The idea of targeting epigenetic abnormalities such as CIMP for cancer therapy has not been implemented for solid tumours, either. Twenty-one years after its discovery, we aim to cover both the fundamental and new aspects of CIMP and its future application as a diagnostic marker and target in anticancer therapies. |
| first_indexed | 2024-03-10T01:17:51Z |
| format | Article |
| id | doaj.art-341b15d4b86440a6b14d3ef6d0e59608 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:17:51Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-341b15d4b86440a6b14d3ef6d0e596082023-11-23T14:05:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-0123283010.3390/ijms23020830CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere?Karpiński Paweł0Sąsiadek Maria Małgorzata1Depatment of Genetics, Wroclaw Medical University, 50-368 Wrocław, PolandDepatment of Genetics, Wroclaw Medical University, 50-368 Wrocław, PolandThe CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been extensively studied, mainly in colorectal cancers (CRC) and gliomas. Consequently, knowledge on molecular and pathological characteristics of CIMP in CRC and other tumour types has rapidly expanded. Concordant and widespread hypermethylation of multiple CpG islands observed in CIMP in multiple cancers raised hopes for future epigenetically based diagnostics and treatments of solid tumours. However, studies on CIMP in solid tumours were hampered by a lack of generalisability and reproducibility of epigenetic markers. Moreover, CIMP was not a satisfactory marker in predicting clinical outcomes. The idea of targeting epigenetic abnormalities such as CIMP for cancer therapy has not been implemented for solid tumours, either. Twenty-one years after its discovery, we aim to cover both the fundamental and new aspects of CIMP and its future application as a diagnostic marker and target in anticancer therapies.https://www.mdpi.com/1422-0067/23/2/830epigeneticsmethylator phenotypeCIMPDNA methylation |
| spellingShingle | Karpiński Paweł Sąsiadek Maria Małgorzata CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere? International Journal of Molecular Sciences epigenetics methylator phenotype CIMP DNA methylation |
| title | CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere? |
| title_full | CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere? |
| title_fullStr | CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere? |
| title_full_unstemmed | CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere? |
| title_short | CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere? |
| title_sort | cpg island methylator phenotype a hope for the future or a road to nowhere |
| topic | epigenetics methylator phenotype CIMP DNA methylation |
| url | https://www.mdpi.com/1422-0067/23/2/830 |
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