The Central Nervous Mechanism of Stress-Promoting Cancer Progression
Evidence shows that stress can promote the occurrence and development of tumors. In recent years, many studies have shown that stress-related hormones or peripheral neurotransmitters can promote the proliferation, survival, and angiogenesis of tumor cells and impair the body’s immune response, causi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/20/12653 |
| _version_ | 1797472669930618880 |
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| author | Yuchuan Hong Lu Zhang Nian Liu Xirong Xu Dan Liu Jie Tu |
| author_facet | Yuchuan Hong Lu Zhang Nian Liu Xirong Xu Dan Liu Jie Tu |
| author_sort | Yuchuan Hong |
| collection | DOAJ |
| description | Evidence shows that stress can promote the occurrence and development of tumors. In recent years, many studies have shown that stress-related hormones or peripheral neurotransmitters can promote the proliferation, survival, and angiogenesis of tumor cells and impair the body’s immune response, causing tumor cells to escape the “surveillance” of the immune system. However, the perception of stress occurs in the central nervous system (CNS) and the role of the central nervous system in tumor progression is still unclear, as are the underlying mechanisms. This review summarizes what is known of stress-related CNS-network activation during the stress response and the influence of the CNS on tumors and discusses available adjuvant treatment methods for cancer patients with negative emotional states, such as anxiety and depression. |
| first_indexed | 2024-03-09T20:04:38Z |
| format | Article |
| id | doaj.art-341b5e0be26b4960a3ea790006a14f3a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:04:38Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-341b5e0be26b4960a3ea790006a14f3a2023-11-24T00:34:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201265310.3390/ijms232012653The Central Nervous Mechanism of Stress-Promoting Cancer ProgressionYuchuan Hong0Lu Zhang1Nian Liu2Xirong Xu3Dan Liu4Jie Tu5Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases, CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaShenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases, CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaShenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases, CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaShenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases, CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaShenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases, CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaShenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases, CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaEvidence shows that stress can promote the occurrence and development of tumors. In recent years, many studies have shown that stress-related hormones or peripheral neurotransmitters can promote the proliferation, survival, and angiogenesis of tumor cells and impair the body’s immune response, causing tumor cells to escape the “surveillance” of the immune system. However, the perception of stress occurs in the central nervous system (CNS) and the role of the central nervous system in tumor progression is still unclear, as are the underlying mechanisms. This review summarizes what is known of stress-related CNS-network activation during the stress response and the influence of the CNS on tumors and discusses available adjuvant treatment methods for cancer patients with negative emotional states, such as anxiety and depression.https://www.mdpi.com/1422-0067/23/20/12653cancercentral nervous systemsympathetic nervous systemadrenergic receptorneuropeptide Y receptorHPA axis |
| spellingShingle | Yuchuan Hong Lu Zhang Nian Liu Xirong Xu Dan Liu Jie Tu The Central Nervous Mechanism of Stress-Promoting Cancer Progression International Journal of Molecular Sciences cancer central nervous system sympathetic nervous system adrenergic receptor neuropeptide Y receptor HPA axis |
| title | The Central Nervous Mechanism of Stress-Promoting Cancer Progression |
| title_full | The Central Nervous Mechanism of Stress-Promoting Cancer Progression |
| title_fullStr | The Central Nervous Mechanism of Stress-Promoting Cancer Progression |
| title_full_unstemmed | The Central Nervous Mechanism of Stress-Promoting Cancer Progression |
| title_short | The Central Nervous Mechanism of Stress-Promoting Cancer Progression |
| title_sort | central nervous mechanism of stress promoting cancer progression |
| topic | cancer central nervous system sympathetic nervous system adrenergic receptor neuropeptide Y receptor HPA axis |
| url | https://www.mdpi.com/1422-0067/23/20/12653 |
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